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. 2021 Oct 26;57(85):11260-11263.
doi: 10.1039/d1cc04744b.

Intramolecular charge transfer enhancing strategy based MAO-A specific two-photon fluorescent probes for glioma cell/tissue imaging

Haixiao Fang  1 , Riri Shi  1 , Ding Chen  1 , Yunwei Qu  1 , Qiong Wu  1 , Xuekang Yang  2 , Xiaomei Lu  1 , Cheng-Wu Zhang  1 , Lin Li  1   3 , Kah-Leong Lim  4
Affiliations

Intramolecular charge transfer enhancing strategy based MAO-A specific two-photon fluorescent probes for glioma cell/tissue imaging

Haixiao Fang et al. Chem Commun (Camb). .

Abstract

MAO-A promotes the proliferation of human glioma cells. Herein, we report a series of MAO-A specific two-photon small molecular fluorescent probes (A1-5) based on an intramolecular charge transfer enhancing strategy. The activity of endogenous MAO-A can be selectively imaged using A3 as a representative probe in different biological samples including human glioma cells/tissues via two-photon fluorescence microscopy. The study provides new tools for the visual detection of glioma.

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