Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Dec;52(6):881-886.
doi: 10.1111/age.13141. Epub 2021 Oct 12.

Genome-wide association study of resistance/susceptibility to infectious bovine keratoconjunctivitis in Brazilian Hereford cattle

H B Comin  1   2 , B P Sollero  3 , E B Gapar  3 , R Domingues  3 , F F Cardoso  1   2   3
Affiliations

Genome-wide association study of resistance/susceptibility to infectious bovine keratoconjunctivitis in Brazilian Hereford cattle

H B Comin et al. Anim Genet. 2021 Dec.

Abstract

Genome-wide association studies were conducted to identify the more informative genomic regions and SNPs, as well as to identify candidate genes associated with infectious bovine keratoconjunctivitis (IBK) resistance/susceptibility in Hereford cattle. A Bayes B statistical approach was initially applied in genome-wide association studies by using deregressed estimated breeding values for IBK resistance/susceptibility. To estimate the combined effect of a genomic region that is potentially associated with QTL, 2504 non-overlapping 1-Mb windows that varied in SNP number were defined, with the most informative 24 windows including 427 SNPs and explaining more than 20% of the estimated genetic variance for IBK resistance/susceptibility. These regions were explored with respect to their biological functions through functional analysis to map potential candidate genes. The significant SNPs were mapped on chromosomes 1, 3, 5, 6, 7, 8, 10, 11, 12, 13, 14, 15, 18, 20, 23, and 28, and candidate genes were detected as related to the IBK. Most informative SNPs in term of genetic variance were located in proximity of genes related to phenotypic expression of lesions and biological processes associated to the IBK. Knowledge about phenotypic and genomic variation generated in the present study can be used to on design selection strategies to improve the resistance to IBK of Hereford cattle herds.

Keywords: Bayesian inference; beef cattle; candidate genes; functional analysis.

PubMed Disclaimer

References

    1. Casas E. & Snowder G.D. (2008) A putative quantitative trait locus on chromosome 20 associated with bovine pathogenic disease incidence. Journal of Animal Science 86, 2455-60.
    1. Casas E. & Stone R.T. (2006) Putative quantitative trait loci associated with the probability of contracting infectious bovine keratoconjunctivitis1. Journal of Animal Science 84, 3180-4.
    1. Clayton D. (2020) snpStats: SnpMatrix and XSnpMatrix classes and methods. R package version 1.40.0. https://doi.org/10.18129/B9.bioc.snpStats.
    1. Conceição F.R. & Turnes C.G. (2003) Moraxella bovis: influência das características genotípicas e fenotípicas no controle da Ceratoconjuntivite Infecciosa Bovina. Ciência Rural, Santa Maria 33, 778-87.
    1. Cullen P.J. (2008) Endosomal sorting and signalling: an emerging role for sorting nexins. Nature Reviews Molecular Cell Biology 9(7), 574-582. https://doi.org/10.1038/nrm2427.

LinkOut - more resources