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. 2021 Dec;13(1_suppl):1671S-1674S.
doi: 10.1177/19476035211049562. Epub 2021 Oct 12.

Novel Use of Intraarticular Granulocyte Colony Stimulating Factor (hG-CSF) Combined with Activated Autologous Peripheral Blood Stem Cells Mobilized with Systemic hG-CSF: Safe and Efficient in Early Osteoarthritis

Konstantinos I Papadopoulos  1 , Mantana Paisan  1 , Warachaya Sutheesophon  1 , Thana Turajane  2
Affiliations

Novel Use of Intraarticular Granulocyte Colony Stimulating Factor (hG-CSF) Combined with Activated Autologous Peripheral Blood Stem Cells Mobilized with Systemic hG-CSF: Safe and Efficient in Early Osteoarthritis

Konstantinos I Papadopoulos et al. Cartilage. 2021 Dec.

Abstract

Osteoarthritis (OA) tends to occur in older individuals frequently burdened with comorbidities and diverse pharmacological interactions. As articular cartilage has low regenerative power, potent local tissue engineering approaches are needed to support chondrogenic differentiation. Acellular preparation methods as well as approaches to coax endogenous reparative cells into the joint space appear to have limited success. Supported by our in-vitro and clinical studies, we propose that our novel intra-articular administration of human granulocyte colony stimulating factor (IA-hG-CSF) combined with autologous activated peripheral blood stem cells (AAPBSC) is safe and offers treatment advantages not seen with other cellular interventions in early osteoarthritis.

Keywords: autologous PBSC; hG-CSF; osteoarthritis.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: KIP, WS, MP are employees of THAI StemLife, and KIP and WS hold shares in THAI StemLife. TT reports no conflicts of interest.

References

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