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. 2022 Apr;45(2):627-638.
doi: 10.1007/s10753-021-01572-2. Epub 2021 Oct 12.

Increased Plasma YKL-40 Level and Chitotriosidase Activity in Cystic Fibrosis Patients

Dilara Bal Topcu  1 , Gokcen Tugcu  2 , Berrin Er  3 , Sanem Eryilmaz Polat  2 , Mina Hizal  2 , Ebru Elmas Yalcin  2 , Deniz Dogru Ersoz  2 , Lutfi Coplu  3 , Ugur Ozcelik  2 , Nural Kiper  2 , Incilay Lay  4 , Yesim Oztas  4
Affiliations

Increased Plasma YKL-40 Level and Chitotriosidase Activity in Cystic Fibrosis Patients

Dilara Bal Topcu et al. Inflammation. 2022 Apr.

Abstract

We investigated plasma YKL-40 levels and chitotriosidase (CHIT1) activity in patients with cystic fibrosis (CF) lung disease and evaluated clinically relevant factors that may affect their levels. Plasma samples were obtained from pediatric (n = 19) and adult patients (n = 15) during exacerbation, discharge, and stable period of the disease. YKL-40 levels and chitotriosidase activity were measured by enzyme-linked immunosorbent assay and fluorometric assay, respectively. Data were compared with healthy children and adults of similar age. YKL-40 levels of pediatric and adult CF patients at all periods were significantly higher than controls (p < 0.001 and p < 0.05). CHIT1 activities of adult patients at all periods were significantly higher compared to controls (p < 0.05). On the other hand, CHIT1 activities of pediatric CF patients were similar with controls. YKL-40 levels of exacerbation period of adult CF patients were negatively correlated with forced vital capacity (FVC) (r = - 0.800, p = 0.014) and forced expiratory volume in 1 s (FEV1) (r = - 0.735, p = 0.008). YKL-40 levels in the exacerbation period of pediatric CF patients were negatively correlated with FVC (r = - 0.697, p = 0.0082) and FEV1 (r = - 0.720, p = 0.006). CHIT1 activity may be a valuable marker of chronic inflammation in adult CF patients who suffer from CF for a longer period compared to pediatric patients. Increased YKL-40 levels in both pediatric and adult patients compared to controls may point to a role in between CF pathology.

Keywords: Chitotriosidase activity; Cystic fibrosis; Exacerbation; Inflammation; Respiratory function test; YKL-40.

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