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Review
. 2021 Sep 26;22(19):10381.
doi: 10.3390/ijms221910381.

From Emollients to Biologicals: Targeting Atopic Dermatitis

Lorenzo Salvati  1 , Lorenzo Cosmi  1 , Francesco Annunziato  1
Affiliations
Review

From Emollients to Biologicals: Targeting Atopic Dermatitis

Lorenzo Salvati et al. Int J Mol Sci. .

Abstract

Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and significantly impacts patients' lives, particularly in its severe forms. AD clinical presentation varies over the course of the disease, throughout different age groups, and across ethnicities. AD is characterized by a spectrum of clinical phenotypes as well as endotypes. Starting from the current description of AD pathogenesis, this review explores the rationale of approved AD therapies from emollients to biologicals and introduces novel promising drugs.

Keywords: JAK-inhibitors; atopic dermatitis; barrier repair therapy; dupilumab; emollients; nemolizumab; skin; therapy; type 2 inflammation.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Atopic dermatitis therapeutic stepwise approach adapted from [24,25,26].
Figure 2
Figure 2
Main molecular pathways in atopic dermatitis targeted by emollients and biologicals. Approved available treatments are in blue boxes.
See this image and copyright information in PMC

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