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Review
. 2021 Oct 6;22(19):10808.
doi: 10.3390/ijms221910808.

Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles

Elena G Varlamova  1 , Egor A Turovsky  1 , Ekaterina V Blinova  2
Affiliations
Review

Therapeutic Potential and Main Methods of Obtaining Selenium Nanoparticles

Elena G Varlamova et al. Int J Mol Sci. .

Abstract

This review presents the latest data on the importance of selenium nanoparticles in human health, their use in medicine, and the main known methods of their production by various methods. In recent years, a multifaceted study of nanoscale complexes in medicine, including selenium nanoparticles, has become very important in view of a number of positive features that make it possible to create new drugs based on them or significantly improve the properties of existing drugs. It is known that selenium is an essential trace element that is part of key antioxidant enzymes. In mammals, there are 25 selenoproteins, in which selenium is a key component of the active site. The important role of selenium in human health has been repeatedly proven by several hundred works in the past few decades; in recent years, the study of selenium nanocomplexes has become the focus of researchers. A large amount of accumulated data requires generalization and systematization in order to improve understanding of the key mechanisms and prospects for the use of selenium nanoparticles in medicine, which is the purpose of this review.

Keywords: selenium; selenium nanoparticles; therapeutic potential.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Methods for obtaining SeNPs and their uses.
Figure 2
Figure 2
Known beneficial effects of SeNP in various diseases.
Figure 3
Figure 3
Ca2+-dependent mechanism of anticancer action of SeNP. Designations: ER, endoplasmic reticulum; Cx43, connexin hemichannels; IP3R-inositol trisphosphate receptor; IP3, inositol trisphosphate; RyR, ryanodine receptor, PLC, phospholipase C; ATP, adenosine triphosphate.
See this image and copyright information in PMC

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