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. 1986 Oct;83(20):7947-50.
doi: 10.1073/pnas.83.20.7947.

Oral immunization and protection of raccoons (Procyon lotor) with a vaccinia-rabies glycoprotein recombinant virus vaccine

C E Rupprecht, T J Wiktor, D H Johnston, A N Hamir, B Dietzschold, W H Wunner, L T Glickman, H Koprowski

Oral immunization and protection of raccoons (Procyon lotor) with a vaccinia-rabies glycoprotein recombinant virus vaccine

C E Rupprecht et al. Proc Natl Acad Sci U S A. 1986 Oct.

Abstract

Animal rabies control has been frustrated by the existence of multiple wildlife reservoirs and the lack of efficacious oral vaccines. In this investigation, raccoons fed a vaccinia-rabies glycoprotein recombinant virus in a sponge bait developed rabies virus-neutralizing antibody (0.6-54.0 units) and resisted street rabies virus infection 28 and 205 days after feeding. Additional raccoons immunized by oral infusion with attenuated antigenic variants of rabies virus strains CVS-11 and ERA failed to develop rabies virus-neutralizing antibody. This work demonstrates the feasibility of a recombinant virus vaccine containing the rabies glycoprotein gene for immunization of raccoons, and possibly other wildlife, to obtain long-term protection against rabies.

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References

    1. J Virol. 1985 Nov;56(2):426-33 - PubMed
    1. Epidemiol Rev. 1980;2:71-96 - PubMed
    1. Am J Epidemiol. 1972 Sep;96(3):231-5 - PubMed
    1. Proc Natl Acad Sci U S A. 1983 Jan;80(1):70-4 - PubMed
    1. Infect Immun. 1982 Jan;35(1):213-21 - PubMed

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