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Review
. 2021 Sep 22;10(19):4306.
doi: 10.3390/jcm10194306.

Long-Term Outcome in Systemic Lupus Erythematosus; Knowledge from Population-Based Cohorts

Sigrid Reppe Moe  1 , Hilde Haukeland  1   2 , Øyvind Molberg  1   3 , Karoline Lerang  1
Affiliations
Review

Long-Term Outcome in Systemic Lupus Erythematosus; Knowledge from Population-Based Cohorts

Sigrid Reppe Moe et al. J Clin Med. .

Abstract

Background: Accurate knowledge of outcomes in Systemic Lupus Erythematosus (SLE) is crucial to understanding the true burden of the disease. The main objective of this systematic review was to gather all population-based studies on mortality, end-stage renal disease (ESRD) and cancer in SLE.

Method: We performed a systematic literature search in two electronic databases (MEDLINE and Embase) to identify all population-based articles on SLE and survival, mortality, ESRD and cancer. The SLE diagnosis had to be verified. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA).

Results: We included 40/1041 articles on mortality (27), ESRD (11) and cancer (3), of which six were defined as inception studies. In the total SLE cohort, the standardized mortality ratio ranged from 1.9 to 4.6. Cardiovascular disease was the most frequent cause of death in studies with follow-up times over 15 years. SLE progressed to ESRD in 5-11% of all SLE patients. There are no data supporting increased cancer incidence from population-based inception cohorts.

Conclusion: There is a need for more population-based studies on outcomes of SLE, especially inception studies, with the use of control groups and follow-up times over 15 years.

Keywords: Systemic Lupus Erythematosus; cancer; end-stage renal disease; epidemiology; mortality; outcome; survival.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of literature search and study inclusion. Studies identified through MEDLINE (Ovid) and Embase (Ovid) through 25 June 2021.
See this image and copyright information in PMC

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