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Meta-Analysis
. 2022 May;32(3):e2304.
doi: 10.1002/rmv.2304. Epub 2021 Oct 13.

The prevalence, predictors and outcomes of acute liver injury among patients with COVID-19: A systematic review and meta-analysis

Harapan Harapan  1   2   3 , Jonny Karunia Fajar  4 , Supriono Supriono  5 , Gatot Soegiarto  6 , Laksmi Wulandari  7 , Fiha Seratin  8 , Nyoman Gede Prayudi  9 , Dara Puspita Dewi  10 , Maria Theresia Monica Elsina  11 , Lasarus Atamou  11 , Sinta Wiranata  12 , Dhito Pemi Aprianto  10 , Erlin Friska  13 , D Fitria Sari Firdaus  13 , Makdum Alaidin  14 , Firdha Aprillia Wardhani  15 , Milda Husnah  16 , Nurdina Wahyu Hidayati  15 , Yeni Hendriyanti  15 , Kristia Wardani  4 , Arde Evatta  4 , Reizal Audi Manugan  4 , Wiryawan Pradipto  4 , Ade Rahmawati  4 , Fredo Tamara  4 , Aditya Indra Mahendra  4 , Firzan Nainu  17 , Budi Santoso  18 , Chandra Adi Irawan Primasatya  19 , Nindy Tjionganata  20 , Hendarto Arif Budiman  19
Affiliations
Meta-Analysis

The prevalence, predictors and outcomes of acute liver injury among patients with COVID-19: A systematic review and meta-analysis

Harapan Harapan et al. Rev Med Virol. 2022 May.

Abstract

The data on the predictors and prognosis of acute liver injury (ALI) among patients in coronavirus disease 2019 (COVID-19) patients are limited. The aim of this study was to determine the prevalence, predictors and outcomes of ALI among patients with COVID-19. A systematic review was conducted up to 10 June 2021. The relevant papers were searched from PubMed, Embase, Cochrane and Web of Science, and the data were analysed using a Z test. A total of 1331 papers were identified and 16 papers consisting of 1254 COVID-19 with ALI and 4999 COVID-19 without ALI were analysed. The cumulative prevalence of ALI among patients with COVID-19 was 22.8%. Male and having low lymphocyte levels were more likely to be associated with ALI compared with female and having higher lymphocyte level, odds ratio (OR): 2.70; 95% confidence interval (CI): 2.03, 3.60 and mean difference (MD) -125; 95% CI: -207, -43, respectively. COVID-19 patients with ALI had higher risk of developing severe COVID-19 compared with those without ALI (OR: 3.61; 95% CI: 2.60, 5.02). Our findings may serve as the additional evaluation for the management of ALI in COVID-19 patients.

Keywords: COVID-19; acute liver injury; outcome; predictor; prevalence.

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Conflict of interest statement

Authors have no conflict of interest.

Figures

FIGURE 1
FIGURE 1
A flowchart of article selection
FIGURE 2
FIGURE 2
The summary of acute liver injury (ALI) in patients with coronavirus disease 2019 (COVID‐19). (a) The global prevalence of ALI in patients with COVID‐19. (b) Association of gender (male) with ALI in COVID‐19 patients. (c) Association of low level of lymphocyte with ALI in COVID‐19 patients. (d) Association between ALI and the severity of COVID‐19
See this image and copyright information in PMC

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