Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 1986 Nov;23(3):253-6.
doi: 10.1016/0165-4608(86)90185-8.

An apparent tandem quadruplication of chromosome 21 in a case of childhood acute lymphoblastic leukemia

I D Dubé, H el-Solh
Case Reports

An apparent tandem quadruplication of chromosome 21 in a case of childhood acute lymphoblastic leukemia

I D Dubé et al. Cancer Genet Cytogenet. 1986 Nov.

Abstract

A case of childhood ALL is presented in which the leukemic clone had both normal chromosomes #21 replaced by a single marker chromosome that contained four copies of chromosome #21 arranged in tandem. This unique report further emphasizes the role played by multiple copies of chromosome #21 in acute leukemia. The observation of one cell in which the marker appeared to consist of only three copies of chromosome #21 arranged in tandem raises the possibility that the marker chromosome arose as a result of a stepwise amplification process.

PubMed Disclaimer

Publication types

Substances

LinkOut - more resources