Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2021 Oct 14;385(16):1511-1520.
doi: 10.1056/NEJMcpc2027096.

Case 31-2021: A 21-Year-Old Man with Sore Throat, Epistaxis, and Oropharyngeal Petechiae

Hanno Hock  1 , Hillary R Kelly  1 , Eric A Meyerowitz  1 , Matthew J Frigault  1 , Lucas R Massoth  1
Affiliations
Case Reports

Case 31-2021: A 21-Year-Old Man with Sore Throat, Epistaxis, and Oropharyngeal Petechiae

Hanno Hock et al. N Engl J Med. .
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1. Clinical Photograph.
A photograph obtained on the day of admission shows a palatal petechia.
Figure 2
Figure 2. Peripheral-Blood and Bone Marrow Specimens.
Wright–Giemsa staining of a peripheral-blood smear (Panel A) shows a circulating plasmacytoid lymphocyte; platelets are notably absent, a finding consistent with thrombocytopenia. Hematoxylin and eosin staining of bone marrow (Panel B) shows markedly hypocellular marrow. At higher magnification (Panel C), the residual cellularity is composed mainly of lymphocytes (arrowhead) and plasma cells (arrow). In situ hybridization of bone marrow to detect severe acute respiratory syndrome coronavirus 2 (Panel D) is negative, without the red chromogen staining that indicates the presence of viral RNA; the inset shows an example of positive cellular staining in human lung tissue.
Figure 3
Figure 3. CT Scan of the Neck.
CT of the neck was performed after the administration of intravenous contrast material in a soft-tissue algorithm. An axial image (Panel A) shows hypoattenuating peritonsillar phlegmon (circled), which is causing partial effacement of the oropharyngeal airway. A coronal image (Panel B) shows the rim of the hypoattenuating phlegmon in the peritonsillar space (arrow) adjacent to the enlarged right palatine tonsil (asterisk). There is no evidence of a well-defined rim-enhancing abscess.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Fan BE, Chong VCL, Chan SSW, et al. Hematologic parameters in patients with COVID-19 infection. Am J Hematol 2020;95(6):E131-E134. - PubMed
    1. Zulfiqar A-A, Lorenzo-Villalba N, Hassler P, Andrès E. Immune thrombocytopenic purpura in a patient with Covid-19. N Engl J Med 2020;382(18):e43-e43. - PMC - PubMed
    1. Issa N, Lacassin F, Camou F. First case of persistent pancytopenia associated with SARS-CoV-2 bone marrow infiltration in an immunocompromised patient. Ann Oncol 2020;31:1418-1419. - PMC - PubMed
    1. Dimopoulos G, de Mast Q, Markou N, et al. Favorable Anakinra responses in severe Covid-19 patients with secondary hemophagocytic lymphohistiocytosis. Cell Host Microbe 2020;28(1):117-123.e1. - PMC - PubMed
    1. Ramos-Casals M, Brito-Zerón P, López-Guillermo A, Khamashta MA, Bosch X. Adult haemophagocytic syndrome. Lancet 2014;383:1503-1516. - PubMed

Publication types