Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2021 Oct 12;54(10):2182-2185.
doi: 10.1016/j.immuni.2021.09.017.

25-hydroxycholesterol: Gatekeeper of intestinal IgA

Christopher J M Piper  1 , Claudia Mauri  2
Affiliations
Free article
Comment

25-hydroxycholesterol: Gatekeeper of intestinal IgA

Christopher J M Piper et al. Immunity. .
Free article

Abstract

High levels of cholesterol and diets high in fat are associated with immune dysfunction and inflammatory disease. In this issue of Immunity, Trindade et al. (2021) report how the cholesterol metabolite 25-hydroxycholesterol restrains IgA plasma cell differentiation from germinal-center B cells in the Peyer's patches through regulation of the sterol-sensing transcription factor SREBP2, independently of EBI2-mediated migration.

PubMed Disclaimer

Comment on

LinkOut - more resources