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Review
. 1992 Mar;3(1):13-19.
doi: 10.1111/j.1365-3164.1992.tb00138.x.

Epidermotropic Cutaneous T-Cell Lymphoma (mycosis fungoides) in Syrian Hamsters (Mesocricetus auratus). A Report of Six Cases and the Demonstration of T-Cell Specificity

Richard G Harvey  1 , Trevor J Whitbread  2 , Luis Ferrer  3 , John E Cooper  4
Affiliations
Review

Epidermotropic Cutaneous T-Cell Lymphoma (mycosis fungoides) in Syrian Hamsters (Mesocricetus auratus). A Report of Six Cases and the Demonstration of T-Cell Specificity

Richard G Harvey et al. Vet Dermatol. 1992 Mar.

Abstract

Abstract- Epidermotropic cutaneous T-cell lymphoma was diagnosed in six Syrian hamsters (Mesocricetus auratus) with a generalised dermatosis characterised by pruritus, alopecia and exfoliative erythroderma. Plaques and nodules were evident in one animal. Clinical and histopathological findings were suggestive of mycosis fungoides and electron microscopical investigations in one case were supportive. Immuno-histochemical stains for CD3 antigen were strongly positive in all cases. Résumé- Un lyphome T cutané a été diagnostiqué chez six hamsters de Sibérie (Mesocricetus auratus) avec une dermatose généralisée, caractérisée par un prurit, une alopécle et une érythrodermie exfoliative. Des plaques et des nodules ont été observées sur un animal. Les données cliniques et histopathologiques étaient évocatrices d'un mycosis fungoïdes et les examens en microscopie électronique étaient compatibles dans un cas. Les marquages immuno-histochimiques de l'antigène CD3 étaient très positifs dans tous les cas. Zusammenfassung- Bei sechs Syrischen Goldhamstern (Mesocricetus auratus) wurde ein epidermotropes kutanes T-Zell-Lymphom mit einer generalisierten Dermatose diagnostiziert, die durch Pruritus, Alopezie und eine exfoliative Erythrodermie gekennzeichnet war. Bei einem Tier traten auch Plagues und Knoten auf. Die klinischen und histopathologischen Befunde deuteten auf Mycosis fungoides hin. Elektronenmikroskopische Untersuchungen unterstützten diesen Verdacht in einem Fall. Immunhistochemische Färbungen auf CD3-Antigen waren bei alien Fallen stark positiv. Resumen En un grupo de seis hamsters de siria, (Mesocricetus auratus), se diagnosticó limfoma epidermotrópico cutáneo de linfocitos T, presentando una dermatosis generalizada de tipo pruriginoso, acompañada de alopecia y eritroderma exfoliativo. Las placas y nódulos fueron evidentes en uno de los animales. Los estudios clinicos e histopatológicos indicaron una micosis fungoide, y las investigaciones de microscopía, en uno de los caseos, pareció indicar lo mismo. La tintura inmuno-histoquimica para el antígeno CD3 resultó claramente positiva en todod los casos.

Keywords: CD3; Epidermotropic lymphoma; Mycosis fungoides; Syrian hamster; T cell.

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References

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