ALSUntangled #63: ketogenic diets

Richard Bedlack¹, Paul E Barkhaus², Benjamin Barnes³, Morgan Beauchamp⁴, Tulio Bertorini⁵, Mark B Bromberg⁶, Gregory T Carter⁷, Vinay Chaudry⁸, Merit Cudkowicz⁹, Ce Jackson¹⁰, Gleb Levitsky¹¹, Isaac Lund¹², Christopher McDermott¹³, Steven Novella¹⁴, Natasha Olby¹⁵, Lyle Ostrow¹⁶, Gary L Pattee¹⁷, Terry Heiman-Patterson¹⁸, Dylan Ratner¹⁹, Kristiana Salmon²⁰, Susan Steves²¹, Mark Terrelonge²², Paul Wicks²³, Anne-Marie Wills⁹

Affiliations

¹ Neurology Department, Duke University, Durham, NC, United States.
² Neurology Department, Froedtert & the Medical College of Wisconsin, Kenosha, WI, United States.
³ Neurology Department, Augusta University Medical College of Georgia, Augusta, GA, United States.
⁴ North Carolina State University, Raleigh, NC, United States.
⁵ Neurology Department, The University of Tennessee Health Science Center VolShop Memphis, Memphis, TN, United States.
⁶ Neurology Department, University of Utah Health Hospitals and Clinics, Salt Lake City, UT, United States.
⁷ St Lukes Rehabilitation Hospital, Physical Medicine and Rehabilitation, Chesterfield, MO, United States.
⁸ Neurology Department, University of North Carolina School of Medicine Neuroscience Center, Chapel Hill, NC, United States.
⁹ Neurology Department, Mass General Brigham Inc., Boston, MA, United States.
¹⁰ Neurology Department, The University of Texas Health Science Center at San Antonio - Greehey Academic and Research Campus, San Antonio, TX, United States.
¹¹ Real Health Clinic, Russian Federation.
¹² Green Hope High School, Cary, NC, United States.
¹³ The University of Sheffield Institute for Translational Neuroscience, Sheffield, United Kingdom.
¹⁴ Neurology Department, Yale University, New Haven, CT, United States.
¹⁵ Neurology Department, North Carolina State University, Raleigh, NC, United States.
¹⁶ Neurology Department, Johns Hopkins University, Baltimore, MD, United States.
¹⁷ Neurology Department, University of Nebraska Medical Center College of Medicine, Omaha, NE, United States.
¹⁸ Neurology Department, Temple University, Philadelphia, PA, United States.
¹⁹ Longmeadow High School, Longmeadow, MA, United States.
²⁰ Neurology Department, McGill Centre for Research in Neuroscience, Montreal, Canada.
²¹ Nutrition Department, Duke University, Durham, NC, United States.
²² Neurology Department, University of California San Francisco, San Francisco, CA, United States.
²³ Independent, Lichfield, GB.

PMID: 34645313
DOI: 10.1080/21678421.2021.1990346

Review

ALSUntangled #63: ketogenic diets

Richard Bedlack et al. Amyotroph Lateral Scler Frontotemporal Degener. 2023 Feb.

. 2023 Feb;24(1-2):159-163.

doi: 10.1080/21678421.2021.1990346. Epub 2021 Oct 14.

Authors

Affiliations

¹ Neurology Department, Duke University, Durham, NC, United States.
² Neurology Department, Froedtert & the Medical College of Wisconsin, Kenosha, WI, United States.
³ Neurology Department, Augusta University Medical College of Georgia, Augusta, GA, United States.
⁴ North Carolina State University, Raleigh, NC, United States.
⁵ Neurology Department, The University of Tennessee Health Science Center VolShop Memphis, Memphis, TN, United States.
⁶ Neurology Department, University of Utah Health Hospitals and Clinics, Salt Lake City, UT, United States.
⁷ St Lukes Rehabilitation Hospital, Physical Medicine and Rehabilitation, Chesterfield, MO, United States.
⁸ Neurology Department, University of North Carolina School of Medicine Neuroscience Center, Chapel Hill, NC, United States.
⁹ Neurology Department, Mass General Brigham Inc., Boston, MA, United States.
¹⁰ Neurology Department, The University of Texas Health Science Center at San Antonio - Greehey Academic and Research Campus, San Antonio, TX, United States.
¹¹ Real Health Clinic, Russian Federation.
¹² Green Hope High School, Cary, NC, United States.
¹³ The University of Sheffield Institute for Translational Neuroscience, Sheffield, United Kingdom.
¹⁴ Neurology Department, Yale University, New Haven, CT, United States.
¹⁵ Neurology Department, North Carolina State University, Raleigh, NC, United States.
¹⁶ Neurology Department, Johns Hopkins University, Baltimore, MD, United States.
¹⁷ Neurology Department, University of Nebraska Medical Center College of Medicine, Omaha, NE, United States.
¹⁸ Neurology Department, Temple University, Philadelphia, PA, United States.
¹⁹ Longmeadow High School, Longmeadow, MA, United States.
²⁰ Neurology Department, McGill Centre for Research in Neuroscience, Montreal, Canada.
²¹ Nutrition Department, Duke University, Durham, NC, United States.
²² Neurology Department, University of California San Francisco, San Francisco, CA, United States.
²³ Independent, Lichfield, GB.

PMID: 34645313
DOI: 10.1080/21678421.2021.1990346

Abstract

ALSUntangled reviews alternative and off label treatments with a goal of helping patients make more informed decisions about them. Here we review ketogenic diets. We shows that these have plausible mechanisms, including augmenting cellular energy balance and reducing excitotoxicity, neuroinflammation and oxidative stress. We review a mouse model study, anecdotal reports and trials in ALS and other diseases. We conclude that there is yet not enough data to recommend ketogenic diets for patients with ALS, especially in light of the many side effects these can have.

Keywords: Ketone; alsuntangled; ketogenic diet; mitochondria; therapy; transgenic animals.

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ALSUntangled #63: ketogenic diets

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ALSUntangled #63: ketogenic diets

Authors

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Abstract

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LinkOut - more resources

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Medical

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