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Observational Study
. 2021 Oct 13;11(10):e050387.
doi: 10.1136/bmjopen-2021-050387.

Temporal trends in incidence and mortality rates of laryngeal cancer at the global, regional and national levels, 1990-2017

Jing-Yuan Wang #  1 , Qiang-Wei Zhang #  2 , Kaixue Wen  3 , Chen Wang  3 , Xiaolin Ji  3 , Lixia Zhang  3
Affiliations
Observational Study

Temporal trends in incidence and mortality rates of laryngeal cancer at the global, regional and national levels, 1990-2017

Jing-Yuan Wang et al. BMJ Open. .

Abstract

Objectives: Laryngeal cancer is the most prevalent entity of head and neck cancer. Knowing the trends of incidence and mortality of laryngeal cancer is important for the reduction in related disease burden.

Design: Population-based observational study.

Main outcomes and measures: The incidence and mortality data of laryngeal cancer were retrieved from the Global Burden of Disease study 2017 online database. The estimated average percentage change was used to quantify the trends of laryngeal cancer incidence and mortality at the global, regional and national levels.

Results: Globally, the numbers of incident cases and deaths due to laryngeal cancer increased 58.7% and 33.9%, respectively, from 1990 to 2017. However, the overall age-standardised incidence rate (ASIR) and age-standardised mortality rate decreased by 0.99% (95% CI 0.83% to 1.14%) and 1.62% (95% CI 1.50% to 1.74%) per year, respectively. These decreases were ubiquitous worldwide. However, unfavourable trends in the ASIR of laryngeal cancer were also observed in a total of 51 developing countries.

Conclusions: The incidence and mortality rates of laryngeal cancer have significantly decreased at the global level and in most countries over the past three decades. The regions that showed an increasing incidence trend deserve more attention.

Keywords: epidemiology; laryngology; public health.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Epidemiological features of laryngeal cancer incidence. (A) The temporal trends of incident case number and (B) age-standardised incidence rate (ASIR) of laryngeal cancer at the global level between 1990 and 2017. (C) The temporal trend of ASIR of laryngeal cancer at the regional level between 1990 and 2017. (D) The ASIR of laryngeal cancer at the national level in 2017. (E) The temporal trend of ASIR of laryngeal cancer at the national level between 1990 and 2017. EAPC, estimated average percentage change; SDI, socio-demographic index.
Figure 2
Figure 2
Epidemiological features of laryngeal cancer mortality. (A) The temporal trends of incident death number and (B) age-standardised mortality rate (ASMR) of laryngeal cancer at the global level between 1990 and 2017. (C) The temporal trend of ASMR of laryngeal cancer at the regional level between 1990 and 2017. (D) The ASMR of laryngeal cancer at the national level in 2017. (E) The temporal trend of ASMR of laryngeal cancer at the national level between 1990 and 2017. EAPC, estimated average percentage change; SDI, socio-demographic index.
Figure 3
Figure 3
The associations between the national socio-demographic index (SDI) and laryngeal cancer-related indexes. (A) The association between age-standardised incidence rate (ASIR) and age-standardised mortality rate (ASMR) of laryngeal cancer in 2017; (B) the association between changing trends of ASIR and ASMR; (C) the correlations of SDI with ASIR of laryngeal cancer; (D) the correlations of SDI with ASMR of laryngeal cancer; (E) the correlations of SDI with the changing trends of ASIR of laryngeal cancer; (F) the correlations of SDI with the changing trends of ASMR of laryngeal cancer. EAPC, estimated average percentage change.
See this image and copyright information in PMC

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