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Review
. 2021 Sep 29:2021:8483668.
doi: 10.1155/2021/8483668. eCollection 2021.

Cell-Based Transplantation versus Cell Homing Approaches for Pulp-Dentin Complex Regeneration

Geraldine M Ahmed  1   2 , Eman A Abouauf  1   3 , Nermeen AbuBakr  1   4 , Asmaa M Fouad  2 , Christof E Dörfer  5 , Karim M Fawzy El-Sayed  1   5   6
Affiliations
Review

Cell-Based Transplantation versus Cell Homing Approaches for Pulp-Dentin Complex Regeneration

Geraldine M Ahmed et al. Stem Cells Int. .

Abstract

Regenerative dentistry has paved the way for a new era for the replacement of damaged dental tissues. Whether the causative factor is dental caries, trauma, or chemical insult, the loss of the pulp vitality constitutes one of the major health problems worldwide. Two regenerative therapies were introduced for a fully functional pulp-dentin complex regeneration, namely, cell-based (cell transplantation) and cell homing (through revascularization or homing by injection of stem cells in situ or intravenously) therapies, with each demonstrating advantages as well as drawbacks, especially in clinical application. The present review is aimed at elaborating on these two techniques in the treatment of irreversibly inflamed or necrotic pulp, which is aimed at regenerating a fully functional pulp-dentin complex.

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Cell-based transplantation method and sources of stem cells used for pulp-dentin complex regeneration.
Figure 2
Figure 2
MSC homing mechanisms and different approaches for enhancing MSC homing.
Figure 3
Figure 3
Different sources of stem/progenitor cells in the oral cavity and steps of revascularization.
See this image and copyright information in PMC

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