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. 2021 Oct;37(10):895-901.
doi: 10.1051/medsci/2021088. Epub 2021 Oct 14.

[Chemical exposome and non-targeted approaches]

[Article in French]
Arthur David  1 , Jade Chaker  1 , Luc Multigner  1 , Vincent Bessonneau  1
Affiliations
Free article

[Chemical exposome and non-targeted approaches]

[Article in French]
Arthur David et al. Med Sci (Paris). 2021 Oct.
Free article

Abstract
in English, French

The technological advances in high-resolution mass spectrometry (HRMS), associated with the development of bioinformatics tools, allows the simultaneous detection of tens of thousands of chemical signals in biological matrices, including exogenous (i.e. xenobiotics) and endogenous molecules. These novel approaches based on HRMS, called "non-targeted" approaches, provide a unique opportunity to capture exposures to a wide range of chemicals (i.e. the internal chemical exposome) in populations, and to better understand the links between chemical exposures and the occurrence of chronic diseases.

Title: Exposome chimique et approches « non ciblées » - Un changement de paradigme pour évaluer l’exposition des populations aux contaminants chimiques.

Abstract: Les avancées techniques en spectrométrie de masse à haute résolution (SMHR), concomitantes au développement d’outils bio-informatiques, permettent aujourd’hui la détection simultanée de plusieurs dizaines de milliers de signaux chimiques dans des matrices biologiques, correspondant à des molécules d’origine exogène (dont les xénobiotiques) et à des molécules endogènes. Ces nouvelles approches reposant sur la SMHR, dites « non ciblées » car sans a priori, représentent une opportunité unique pour caractériser à grande échelle l’exposition de populations humaines aux composés chimiques (ce que l’on appelle exposome chimique interne), et ainsi mieux appréhender leur rôle dans la survenue de maladies chroniques.

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References

    1. Cui Y, Balshaw DM, Kwok RK, et al. The exposome: embracing the complexity for discovery in environmental health. Environ Health Perspect 2016 ; 124 : A137–A140.
    1. Bodmer W, Bonilla C. Common and rare variants in multifactorial susceptibility to common diseases. Nat Genet 2008 ; 40 : 695–701.
    1. Manolio TA, Collins FS, Cox NJet al. Finding the missing heritability of complex diseases. Nature 2009 ; 461 : 747–753.
    1. Rappaport SMGenetic factors are not the major causes of chronic diseases. PLoS One 2016 ; 11 : e0154387.
    1. Vermeulen R, Schymanski EL, Barabasi AL, Miller GW. The exposome and health: where chemistry meets biology. Science 2020; 367 : 392–6.

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