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Comment
. 2021 Oct 15;374(6565):eabi6060.
doi: 10.1126/science.abi6060. Epub 2021 Oct 14.

Comment on "Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment"

Tomislav Maricic  1 , Nelly Helmbrecht  1 , Stephan Riesenberg  1 , Dominik Macak  1 , Philipp Kanis  1 , Martin Lackner  1 , Agrafena Daria Pugach-Matveeva  1 , Svante Pääbo  1   2
Affiliations
Comment

Comment on "Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment"

Tomislav Maricic et al. Science. .

Abstract

Trujillo et al. (Research Articles, 12 February 2021, eaax2537) conclude that the reintroduction of an ancestral amino acid substitution in the protein NOVA1 drastically alters the development of brain organoids. We show that cell lines used by the authors carry heterozygous deletions of the target DNA sequence, providing another plausible explanation for the effects observed.

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  • Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment.
    Trujillo CA, Rice ES, Schaefer NK, Chaim IA, Wheeler EC, Madrigal AA, Buchanan J, Preissl S, Wang A, Negraes PD, Szeto RA, Herai RH, Huseynov A, Ferraz MSA, Borges FS, Kihara AH, Byrne A, Marin M, Vollmers C, Brooks AN, Lautz JD, Semendeferi K, Shapiro B, Yeo GW, Smith SEP, Green RE, Muotri AR. Trujillo CA, et al. Science. 2021 Feb 12;371(6530):eaax2537. doi: 10.1126/science.aax2537. Science. 2021. PMID: 33574182 Free PMC article.

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