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Comment
. 2021 Oct 15;374(6565):262-263.
doi: 10.1126/science.abm2240. Epub 2021 Oct 14.

Resealing and rebuilding injured muscle

Elizabeth M McNally  1 , Alexis R Demonbreun  1   2
Affiliations
Comment

Resealing and rebuilding injured muscle

Elizabeth M McNally et al. Science. .

Abstract

Reconstructing an injured muscle involves nuclear and mitochondrial contributions.

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Figures

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Repairing muscle
Within seconds of exercise-induced injury, an annexin-rich cap reseals the disrupted cell membrane, and mitochondria and annexins alleviate excess Ca2+. After several hours, rebuilding involves continued removal of excess Ca2+ and nuclear movement toward the site of injury to form translational hotspots.
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