A word of caution on using tumor biomarker reference change values to guide medical decisions and the need for alternatives

Affiliations

¹ Department of Laboratory Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
² Department of Laboratory Medicine, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³ Clinical Chemistry Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
⁴ Institute of Laboratory Medicine, Munich Biomarker Research Center, Deutsches Herzzentrum München, Technische Universität Munchen, Munich, Germany.

Huub H van Rossum et al. Clin Chem Lab Med. 2021.

. 2021 Oct 15;60(4):553-555.

doi: 10.1515/cclm-2021-0933. Print 2022 Mar 28.

¹ Department of Laboratory Medicine, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
² Department of Laboratory Medicine, Division of Pathology and Laboratory Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
³ Clinical Chemistry Service, Department of Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
⁴ Institute of Laboratory Medicine, Munich Biomarker Research Center, Deutsches Herzzentrum München, Technische Universität Munchen, Munich, Germany.

No abstract available

Keywords: evidence based-medicine; reference change value; tumor biomarker.

Comment in

Biological variation and reference change value as decision criteria in clinical use of tumor biomarkers. Are they really useful?
Dittadi R, Fabricio ASC, Gion M. Dittadi R, et al. Clin Chem Lab Med. 2022 Mar 10;60(6):e136-e137. doi: 10.1515/cclm-2022-0047. Print 2022 May 25. Clin Chem Lab Med. 2022. PMID: 35263822 No abstract available.

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