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. 2021 Nov 18;385(21):2010-2012.
doi: 10.1056/NEJMc2115596. Epub 2021 Oct 15.

Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines

Ai-Ris Y Collier  1 , Jingyou Yu  1 , Katherine McMahan  1 , Jinyan Liu  1 , Abishek Chandrashekar  1 , Jenny S Maron  2 , Caroline Atyeo  2 , David R Martinez  3 , Jessica L Ansel  1 , Ricardo Aguayo  1 , Marjorie Rowe  1 , Catherine Jacob-Dolan  1 , Daniel Sellers  1 , Julia Barrett  1 , Kunza Ahmad  1 , Tochi Anioke  1 , Haley VanWyk  1 , Sarah Gardner  1 , Olivia Powers  1 , Esther A Bondzie  1 , Huahua Wan  1 , Ralph S Baric  3 , Galit Alter  2 , Michele R Hacker  4 , Dan H Barouch  4
Affiliations

Differential Kinetics of Immune Responses Elicited by Covid-19 Vaccines

Ai-Ris Y Collier et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Kinetics of Humoral and Cellular Immune Responses Elicited by the BNT162b2, mRNA-1273, and Ad26.COV2.S Vaccines.
Shown are immune responses after vaccination with BNT162b2, mRNA-1273, and Ad26.COV2.S at peak immunity (2 to 4 weeks after the second dose in recipients of the messenger RNA vaccines or 4 weeks after one dose in recipients of the Ad26.COV2.S vaccine) and at 6 months, 8 months, or both after the first dose. Panel A shows the serum 50% inhibitory dilution (ID50) titers in the live-virus neutralizing antibody assay. Red bars indicate medians, dashed lines the limit of detection for each assay, and each dot a single participant. Panel B shows the serum dilution for 50% reduction (NT50) expressed in relative light units in the pseudovirus neutralizing antibody assay. Panel C shows the binding IgG antibody titers against the receptor-binding domain (RBD) in the serum enzyme-linked immunosorbent assay. Intracellular cytokine-staining assays were performed to measure the percentage of interferon-γ production in T cells; Panel D shows this percentage in CD4+ T cells, and Panel E shows this percentage in CD8+ T cells. Flow cytometric gating was performed to identify T cells (which are CD3+) rather than other CD4+- or CD8+-expressing immune cells. All assays were performed with the use of the SARS-CoV-2 WA1/2020 strain. The Ad26.COV2.S vaccine data in Panels B through E were published previously and are included here for comparative purposes.
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References

    1. Pegu A, O’Connell SE, Schmidt SD, et al. Durability of mRNA-1273 vaccine-induced antibodies against SARS-CoV-2 variants. Science 2021;373:1372-1377. - PMC - PubMed
    1. Falsey AR, Frenck RW Jr, Walsh EE, et al. SARS-CoV-2 neutralization with BNT162b2 vaccine dose 3. N Engl J Med. DOI: 10.1056/NEJMc2113468. - DOI - PMC - PubMed
    1. Barouch DH, Stephenson KE, Sadoff J, et al. Durable humoral and cellular immune responses 8 months after Ad26.COV2.S vaccination. N Engl J Med 2021;385:951-953. - PMC - PubMed

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