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Comment
. 2021 Oct 13;29(10):1477-1479.
doi: 10.1016/j.chom.2021.09.015.

Brain development in premature infants: A bug in the programming system?

Gerard Clarke  1 , Anna Aatsinki  2 , Siobhain M O'Mahony  3
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Comment

Brain development in premature infants: A bug in the programming system?

Gerard Clarke et al. Cell Host Microbe. .
Free article

Abstract

In this issue of Cell Host & Microbe, Seki et al. (2021) demonstrate an overgrowth of Klebsiella in the gut microbiota of extremely premature infants that is predictive of brain damage. The Klebsiella-associated pro-inflammatory signature suggests that aberrant microbiome-gut-brain axis signaling provokes the disruption of neurodevelopmental trajectories to exacerbate brain injury.

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Conflict of interest statement

Declaration of interests G.C. has received honoraria from Janssen, Probi, and Apsen as an invited speaker, is in receipt of research funding from Pharmavite and Fonterra, and is a paid consultant for Yakult and Zentiva. APC Microbiome Ireland has received research support from Mead Johnson, Cremo, 4D Pharma, Suntory Wellness, and Nutricia. The content of this commentary was neither influenced nor constrained by this support.

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