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. 1986 Nov;83(22):8472-6.
doi: 10.1073/pnas.83.22.8472.

Binding of ethidium bromide causes dissociation of the nucleosome core particle

C T McMurray, K E van Holde

Binding of ethidium bromide causes dissociation of the nucleosome core particle

C T McMurray et al. Proc Natl Acad Sci U S A. 1986 Nov.

Abstract

The binding of ethidium bromide to chicken erythrocyte core particles results in a step-wise dissociation of the structure that involves the initial release of one copy each of histones H2A and H2B. Quantitation of the dissociated DNA reveals that a critical amount of drug is required for the dissociation. Above the critical value, the dissociation is time dependent, reversible, and independent of DNA concentration.

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