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. 2021 Sep 15;13(9):10421-10427.
eCollection 2021.

The application of Gensini score and IL-1ra in assessing the condition and prognosis of patients with coronary artery disease

Qian He  1 , Pu Zhang  1 , Yu Li  1 , Chao Cai  1 , Chongquan Wang  1
Affiliations

The application of Gensini score and IL-1ra in assessing the condition and prognosis of patients with coronary artery disease

Qian He et al. Am J Transl Res. .

Abstract

Objective: This study aimed to investigate the value of Gensini score and interleukin-1 receptor antagonist (IL-1ra) in assessing the condition and prognosis of patients with coronary heart disease (CHD).

Methods: According to their condition, 175 patients were divided into stable angina group (SA, 60 cases), unstable angina group (UA, 60 cases) and acute myocardial infarction group (AMI, 55 cases). The Gensini score, GRACE score, IL-1ra and troponin (Tn) were compared in the three groups. The correlation between Gensini score and GRACE score, IL-1ra and Tn, were explored. The patients were divided into death group (21 cases), adverse cardiovascular events group (MACE, 50 cases) and good prognosis group (104 cases) according to clinical outcomes. The ROC curve with regard to Gensini score, IL-1ra and the clinical outcome was plotted.

Results: With the exacerbation of the disease, the Gensini score, GRACE score, IL-1ra and Tn were significantly higher in patients with CHD (P<0.05). Correlation analysis showed a positive association between Gensini score and GRACE score (r=0.9751, P<0.05). IL-1ra showed a positive association with Tn level (r=0.9731, P<0.05); Gensini score and IL-1ra had an area under the curve (AUC) of 0.9350 and 0.9499 for adverse CHD outcome, respectively (P<0.001).

Conclusion: Gensini score and IL-1ra reflect better the severity of CHD in patients with CHD, and also the AUC of 0.9350 and 0.9499 (P<0.001). It can be used in the prognostic evaluation of patients with CHD.

Keywords: Gensini score; IL-1ra; applied value; condition assessment; coronary heart disease; prognosis.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Comparison of the differences between Gensini score and GRACE score in patients with different conditions. #Means P<0.05 in comparison with SA group, and *means P<0.05 in comparison with UA group.
Figure 2
Figure 2
Comparison of IL-1ra and Tn levels in patients with different conditions. #Means P<0.05 in comparison with SA group, and *means P<0.05 in comparison with UA group.
Figure 3
Figure 3
Comparison of the differences between Gensini score and GRACE score in CHD patients with different clinical outcomes. #Means P<0.05 in comparison with death group, and *means P<0.05 in comparison with MACE group.
Figure 4
Figure 4
Comparison of IL-1ra and Tn levels in patients with different clinical outcomes. #Means P<0.05 in comparison with death group, and *means P<0.05 in comparison with MACE group.
Figure 5
Figure 5
Correlation analysis between Gensini score and GRACE score, IL-1ra and Tn level in CHD patients. Gensini score showed a positive correlation with GRACE score (r=0.9751, P<0.05) and IL-1ra showed a positive correlation with Tn level (r=0.9731, P<0.05).
Figure 6
Figure 6
The AUC of Gensini score and IL-1ra for poor prognosis. AUC of Gensini score for poor prognosis was 0.9305 with 95% CI=0.8528-1.0000 (P<0.001) and AUC of IL-1ra for poor prognosis is 0.9499 with 95% CI=0.8942-1.0000 (P<0.001).
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