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. 2021 Sep 15;13(9):10509-10516.
eCollection 2021.

Low-molecular-weight heparin reduces the formation of lower limb deep venous thrombosis in patients with hypertensive intracerebral hemorrhage

He Song  1 , Huanli Men  1 , Chunwang Song  1 , Hongwei Feng  1 , Haopeng Tan  1 , Shuhao Zuo  1
Affiliations

Low-molecular-weight heparin reduces the formation of lower limb deep venous thrombosis in patients with hypertensive intracerebral hemorrhage

He Song et al. Am J Transl Res. .

Abstract

Objective: To demonstrate that low-molecular-weight heparin (LMWH) can reduce the formation of lower limb deep venous thrombosis (DVT) and improve the quality of life (QOL) of patients with hypertensive intracerebral hemorrhage (HICH).

Methods: Totally, 98 patients with HICH were selected according to different treatment and intervention schemes. Patients receiving routine intracranial pressure reduction and blood pressure regulation intervention were included in group A (n=46) and those receiving LMWH calcium on the basis of treatment in group A were included in group B (n=52). The total effective rate of patients was compared between the two groups, and the prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen degradation product (FDP), D-dimer, and inflammatory factor levels as well as complications and QOL scores before and after treatment were recorded and compared.

Results: The FDP and D-dimer showed an increasing trend in both groups after treatment, with the increase being significantly lower in group B than in group A (P<0.001). Serum tumor necrosis factor-α and interleukin-1β levels increased significantly in the two groups after treatment, with the increase being significantly lower in group B than in group A (P<0.05). Complications of pulmonary embolism, DVT, intracranial hemorrhage, and gastrointestinal hemorrhage were better in group B than in group A (P<0.05). In terms of QOL, physical and mental health, material life, and social functioning were significantly higher in patients of group B than for those in group A (P<0.001).

Conclusions: The application of LMWH in patients with HICH can reduce the formation of lower limb DVT.

Keywords: Low-molecular-weight heparin; hypertensive intracerebral hemorrhage; lower limb deep venous thrombosis; quality of life.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Analysis of myocardial injury markers before and after hand treatment. Compared with before treatment, the PT (A) and APTT (B) showed an increasing trend after treatment in both groups, and the increase differed insignificantly between the two groups (P>0.05).
Figure 2
Figure 2
Analysis of FDP and D-dimer before and after treatment. Compared with before treatment, the FDP and D-dimer increased gradually in both groups after treatment, and the increase was significantly lower in group B than in group A (P<0.001). Note: a indicates P<0.001.
Figure 3
Figure 3
Changes in serum TNF-α levels. Serum TNF-α levels did not show any significant difference between the two groups before treatment (P>0.05); however, it increased notably in both groups after treatment, and the increase was significantly lower in group B than in group A (P<0.05). Note: a indicates P<0.001.
Figure 4
Figure 4
Changes in serum IL-1β levels. Serum IL-1β levels differed insignificantly between the two groups before treatment (P>0.05); however, it increased notably in both groups after treatment, and the increase was significantly lower in group B than in group A (P<0.05). Note: a indicates P<0.001.
Figure 5
Figure 5
Comparison of QOL between groups A and B. The QOL-C30 scores of physical and mental health, material life, and social functioning were significantly higher in patients in group B than in those in group A. Note: a indicates P<0.001.
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