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. 2021 Sep 15;13(9):10570-10577.
eCollection 2021.

Effect of gangliosides combined with mouse NGF on the expression of serum HIF-1α, NSE, and sICAM-1 levels in neonates with HIE

Wenling Ding  1   2 , Renchang Liu  3 , Ruobing Shan  4
Affiliations

Effect of gangliosides combined with mouse NGF on the expression of serum HIF-1α, NSE, and sICAM-1 levels in neonates with HIE

Wenling Ding et al. Am J Transl Res. .

Abstract

Objective: This study was intended to evaluate the effects of gangliosides combined with mouse nerve growth factor (NGF) on the expression of serum hypoxia-inducible factor-1α (HIF-1α), neuron-specific enolase (NSE), and soluble intercellular adhesion molecule-1 (sICAM-1) levels in neonates with ischemic-hypoxic encephalopathy (HIE).

Methods: One hundred and thirty neonates with HIE admitted to our hospital from May 2017 to April 2019 were grouped into two groups according to the protocol of a randomized controlled trial, with 65 cases in each group. The control group received ganglioside treatment, while the combined group was treated with ganglioside + NGF for 2 weeks.

Results: The total effective rate of treatment was higher in the combined group (90.77%) than in the control group (76.92%). The recovery time of sucking, consciousness, muscle tone and primitive reflexes was shorter in the combined group than in the control group, and the incidence of neurological sequelae was lower after 1 year in the combined group (4.62%) than in the control group (15.38%) (P < 0.05).

Conclusion: Gangliosides combined with NGF can promote the recovery of muscle tone and reduce neurological sequelae, which may possibly be achieved by repairing damaged neuronal cells, enhancing antioxidant enzyme activity, and promoting the regression of inflammation.

Keywords: HIF-1α; NSE; Neonatal ischemic-hypoxic encephalopathy; ganglioside; mouse nerve growth factor.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Comparison of recovery time (d). Note: (A) Recovery of sucking; (B) Recovery of consciousness; (C) Recovery of muscle tone; (D) Recovery of primitive reflexes. Compared to the control group, ***P < 0.001.
Figure 2
Figure 2
Comparison of NBNA, MDI, and PDI scores. Note: (A) NBNA; (B) MDI; (C) PDI. Compared to the control group, ***P < 0.001; compared to the pre-treatment within same group, ###P < 0.001.
Figure 3
Figure 3
Comparison of neurological function indices. Note: (A) MBP; (B) S100β; (C) 8-OHDG; (D) ADM; (E) NPY. Compared to the control group, ***P < 0.001; compared to the pre-treatment within same group, ###P < 0.001.
Figure 4
Figure 4
Comparison of serum indices. Note: (A) HIF-1α; (B) NSE; (C) sICAM-1; (D) ET-1; (E) GFAP. Compared to the control group, ***P < 0.001; compared to the pre-treatment within same group, ###P < 0.001.
See this image and copyright information in PMC

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