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. 2021 Oct 11;6(5):e142.
doi: 10.1097/j.pbj.0000000000000142. eCollection 2021 Sep-Oct.

IgA nephropathy in IgG kappa multiple myeloma

Maria Eduarda Couto  1 , Domingos Sousa  2 , Hugo Ferreira  3 , Alda Tavares  4 , Isabel Oliveira  1 , Nelson Domingues  1 , Ana Paiva  3 , Teresa Chuva  3 , José Maximino  3 , Rui Manuel Ferreira Henrique  5 , José Mário Mariz  1
Affiliations

IgA nephropathy in IgG kappa multiple myeloma

Maria Eduarda Couto et al. Porto Biomed J. .

Abstract

Multiple myeloma (MM) frequently affects kidney function through multiple mechanisms. Nonetheless, some patients develop kidney injury due to other causes. A 54-year-old woman was diagnosed with IgG kappa MM developed IgA nephropathy without cast nephropathy. Further studies did not show criteria for MM progression or other causes. This case highlights the need for further investigation of kidney injury in MM patients (such as toxicity of previous drugs, infectious events, or immune-mediated disorders).

Keywords: IgA nephropathy; acute kidney injury; corticosteroids; multiple myeloma; purpura.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Light microscopy (hematoxylin & eosin, staining ×20) of the renal biopsy: glomeruli show mesangial hypercellularity, there is a cellular cast within a tubule (∗) and significant polymorphonuclear-predominant interstitial infiltrate.
Figure 2
Figure 2
Immunofluorescence image of the kidney biopsy: IgA ++ in the mesangium. Crystals were not found in the cytoplasm of proximal tube cells, however, light-chain proximal tubulopathy cannot be excluded.
See this image and copyright information in PMC

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