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Review
. 2021 Oct 13;36(7):1291-1295.
doi: 10.1093/arclin/acab049.

How Can Cognitive Reserve Promote Cognitive and Neurobehavioral Health?

Yaakov Stern  1
Affiliations
Review

How Can Cognitive Reserve Promote Cognitive and Neurobehavioral Health?

Yaakov Stern. Arch Clin Neuropsychol. .

Abstract

Objective: This review is aimed at understanding how cognitive reserve and related concepts contribute to promoting neurobehavioral and cognitive health, consistent with goal of the 2020 national academy of neuropsychology (NAN) Annual Meeting.Research indicates that lifestyle factors such as achieving educational and work milestones, participating in leisure and social activities and IQ are all associated with reduced risk of cognitive decline in normal aging and of developing dementia. Many of these lifestyle factors have also been associated with better cognition in other psychiatric and neurological conditions. The cognitive reserve hypothesis posits that these lifestyle factors result in individual differences in the flexibility and adaptability of brain networks that may allow some people to cope better than others with age- or dementia-related brain changes. Recent evidence also supports the idea that specific genetic and lifestyle factors may help preserve a healthy brain or enhance brain reserve, a process that has been called brain maintenance. The complementary concept of brain reserve posits that structural brain features can guard against dementia and related conditions. This review defines these theoretical concepts, their research basis, how they are studied and their clinical applications.

Conclusion: Evidence supports the concept of reserve, which can be influenced by experiences in every stage of life. Focused research in this area can maximize the chance for successful intervention.

Keywords: Dementia; Elderly/Geriatrics/Aging; Neuroimaging (functional); Neuroimaging (structural).

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References

    1. Barnett, J. H., Salmond, C. H., Jones, P. B., & Sahakian, B. J. (2006). Cognitive reserve in neuropsychiatry. Psychological Medicine, 36, 1053–1064. - PubMed
    1. Bennett, D. A., Wilson, R. S., Schneider, J. A., Evans, D. A., Mendes De Leon, C. F., Arnold, S. E.et al. (2003). Education modifies the relation of AD pathology to level of cognitive function in older persons. Neurology, 60(12), 1909–1915. - PubMed
    1. Blessed, G., Tomlinson, B. E., & Roth, M. (1968). The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. The British Journal of Psychiatry, 114(512), 797–811. - PubMed
    1. Farinpour, R., Miller, E. N., Satz, P., Selnes, O. A., Cohen, B. A., Becker, J. T.et al. (2003). Psychosocial risk factors of HIV morbidity and mortality: Findings from the Multicenter AIDS cohort study (MACS). Journal of Clinical and Experimental Neuropsychology, 25, 654–670. - PubMed
    1. Franzmeier, N., Caballero, M. A. A., Taylor, A. N. W., Simon-Vermot, L., Buerger, K., Ertl-Wagner, B.et al. (2017). Resting-state global functional connectivity as a biomarker of cognitive reserve in mild cognitive impairment. Brain Imaging and Behavior, 11(2), 368–382. 10.1007/s11682-016-9599-1. - DOI - PubMed