Cohort Profile: The Ovarian Cancer Cohort Consortium (OC3)

Mary K Townsend¹, Britton Trabert², Renée T Fortner³, Alan A Arslan⁴, Julie E Buring^{5

6

7}, Brian D Carter⁸, Graham G Giles^{9

10

11}, Sarah R Irvin¹², Michael E Jones¹³, Rudolf Kaaks³, Victoria A Kirsh^{14

15}, Synnove F Knutsen¹⁶, Woon-Puay Koh^{17

18}, James V Lacey¹⁹, Hilde Langseth^{20

21}, Susanna C Larsson²², I-Min Lee^{5

6

7}, María Elena Martínez²³, Melissa A Merritt²⁴, Roger L Milne^{9

10

11}, Katie M O'Brien²⁵, Michael J Orlich¹⁶, Julie R Palmer²⁶, Alpa V Patel⁸, Ulrike Peters^{27

28}, Jenny N Poynter²⁹, Kim Robien³⁰, Thomas E Rohan³¹, Lynn Rosenberg²⁶, Sven Sandin^{32

33

34}, Dale P Sandler²⁵, Leo J Schouten³⁵, V Wendy Setiawan³⁶, Anthony J Swerdlow³⁷, Giske Ursin^{38

39

40}, Piet A van den Brandt³⁵, Kala Visvanathan^{41

42}, Elisabete Weiderpass⁴³, Alicja Wolk^{22

44}, Jian-Min Yuan^{45

46}, Anne Zeleniuch-Jacquotte⁴⁷, Shelley S Tworoger¹, Nicolas Wentzensen¹²

Affiliations

¹ Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
² Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
³ Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
⁴ Division of Epidemiology, Departments of Obstetrics and Gynecology, Population Health, and Environmental Medicine, New York University School of Medicine, New York, NY, USA.
⁵ Department of Medicine, Harvard Medical School, Boston, MA, USA.
⁶ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
⁷ Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
⁸ Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.
⁹ Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
¹⁰ Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
¹¹ Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
¹² Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
¹³ Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
¹⁴ Ontario Health Study, Ontario Institute for Cancer Research, Toronto, ON, Canada.
¹⁵ Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
¹⁶ School of Public Health, Loma Linda University, Loma Linda, CA, USA.
¹⁷ Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
¹⁸ Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore.
¹⁹ Beckman Research Institute, City of Hope, Duarte, CA, USA.
²⁰ Department of Research, Cancer Registry of Norway, Oslo, Norway.
²¹ Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
²² Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
²³ Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.
²⁴ Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
²⁵ Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
²⁶ Slone Epidemiology Center, Boston University School of Medicine, Boston, MA, USA.
²⁷ Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
²⁸ Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA.
²⁹ Division of Pediatric Epidemiology and Clinical Research, University of Minnesota, Minneapolis, MN, USA.
³⁰ Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
³¹ Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
³² Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
³³ Department of Psychiatry, Icahn School of Medicine, Mount Sinai, New York, NY, USA.
³⁴ Seaver Autism Center for Research and Treatment, Icahn School of Medicine, Mount Sinai, New York, NY, USA.
³⁵ Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
³⁶ Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
³⁷ Division of Genetics and Epidemiology and Division of Breast Cancer Research, Institute of Cancer Research, London, UK.
³⁸ Cancer Registry of Norway, Oslo, Norway.
³⁹ Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
⁴⁰ Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
⁴¹ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
⁴² Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
⁴³ Office of the Director, International Agency for Research on Cancer, World Health Organization, Lyon, France.
⁴⁴ Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
⁴⁵ UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
⁴⁶ Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
⁴⁷ Department of Population Health and Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA.

PMID: 34652432
PMCID: PMC9425513
DOI: 10.1093/ije/dyab211

Cohort Profile: The Ovarian Cancer Cohort Consortium (OC3)

Mary K Townsend et al. Int J Epidemiol. 2022.

. 2022 Jun 13;51(3):e73-e86.

doi: 10.1093/ije/dyab211.

Authors

Affiliations

¹ Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
² Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
³ Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Heidelberg, Germany.
⁴ Division of Epidemiology, Departments of Obstetrics and Gynecology, Population Health, and Environmental Medicine, New York University School of Medicine, New York, NY, USA.
⁵ Department of Medicine, Harvard Medical School, Boston, MA, USA.
⁶ Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
⁷ Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
⁸ Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.
⁹ Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.
¹⁰ Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.
¹¹ Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.
¹² Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
¹³ Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK.
¹⁴ Ontario Health Study, Ontario Institute for Cancer Research, Toronto, ON, Canada.
¹⁵ Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
¹⁶ School of Public Health, Loma Linda University, Loma Linda, CA, USA.
¹⁷ Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
¹⁸ Singapore Institute for Clinical Sciences, Agency for Science Technology and Research (A*STAR), Singapore, Singapore.
¹⁹ Beckman Research Institute, City of Hope, Duarte, CA, USA.
²⁰ Department of Research, Cancer Registry of Norway, Oslo, Norway.
²¹ Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
²² Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
²³ Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA.
²⁴ Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
²⁵ Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
²⁶ Slone Epidemiology Center, Boston University School of Medicine, Boston, MA, USA.
²⁷ Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
²⁸ Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA.
²⁹ Division of Pediatric Epidemiology and Clinical Research, University of Minnesota, Minneapolis, MN, USA.
³⁰ Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, George Washington University, Washington, DC, USA.
³¹ Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
³² Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
³³ Department of Psychiatry, Icahn School of Medicine, Mount Sinai, New York, NY, USA.
³⁴ Seaver Autism Center for Research and Treatment, Icahn School of Medicine, Mount Sinai, New York, NY, USA.
³⁵ Department of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
³⁶ Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
³⁷ Division of Genetics and Epidemiology and Division of Breast Cancer Research, Institute of Cancer Research, London, UK.
³⁸ Cancer Registry of Norway, Oslo, Norway.
³⁹ Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
⁴⁰ Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA.
⁴¹ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
⁴² Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
⁴³ Office of the Director, International Agency for Research on Cancer, World Health Organization, Lyon, France.
⁴⁴ Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
⁴⁵ UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
⁴⁶ Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
⁴⁷ Department of Population Health and Department of Environmental Medicine, New York University School of Medicine, New York, NY, USA.

PMID: 34652432
PMCID: PMC9425513
DOI: 10.1093/ije/dyab211

No abstract available

PubMed Disclaimer

Figures

**Figure 1**
Timing of questionnaires in the Ovarian Cancer Cohort Consortium, by study. See Table 1 for full study names corresponding to each abbreviation. Triangles indicate a questionnaire mailing or interview. Ovals indicate the study enrolment period. Solid arrow lines indicate studies that are still actively following participants (i.e., planning to send additional questionnaires or conduct additional interviews to collect updated exposure and/or disease information). Dotted arrow lines indicate studies that no longer actively follow participants but are passively collecting participant endpoints via linkage with cancer and death registries. The countries within the European Prospective Investigation into Cancer and Nutrition (EPIC) collect data at different time intervals; data are shown for the country within EPIC with the shortest interval between questionnaires.

**Figure 2**
Unsupervised hierarchical clustering of ovarian cancer subtypes by their associations with risk factors. Unsupervised hierarchical clustering of (A) the four major ovarian cancer histotypes and (B) four ovarian tumour aggressiveness categories (highly aggressive = time between diagnosis and death <1 year; very aggressive = death in 1 to <3 years; moderately aggressive = death in 3 to <5 years; less aggressive = lived ≥5 years). Unless otherwise noted, the categories used in the cluster analysis were ever versus never parous, ever versus never oral contraceptive use, ever versus never tubal ligation, ever versus never endometriosis, age at menarche >15 vs ≤11 years, age at menopause <40 versus 50 to 55 years, ever versus never menopausal hormone therapy use, ever versus never hysterectomy, family history of breast cancer (yes vs no), family history of ovarian cancer (yes vs no), body mass index >35 versus 20 to 25 kg/m2, height (per 5-cm increase), and ever versus never smoking. The colour scale shows the range of β-values for each exposure.

See this image and copyright information in PMC

References

1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A.. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018;68:394–424. - PubMed
1. Buys SS, Partridge E, Black A. et al.; PLCO Project Team. Effect of screening on ovarian cancer mortality: the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial. JAMA 2011;305:2295–303. - PubMed
1. Jacobs IJ, Menon U, Ryan A. et al. Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial. Lancet 2016;387:945–56. - PMC - PubMed
1. Epidemiology Working Group Steering Committee, Ovarian Cancer Association Consortium Members of the EWG SC in alphabetical order:, Doherty JA, Jensen A, Kelemen LE. et al.Current gaps in ovarian cancer epidemiology: the need for new population-based research. J Natl Cancer Inst 2017;109:djx144. - PMC - PubMed
1. Pfeiffer RM, Park Y, Kreimer AR. et al. Risk prediction for breast, endometrial, and ovarian cancer in white women aged 50 y or older: derivation and validation from population-based cohort studies. PLoS Med 2013;10:e1001492. - PMC - PubMed

Publication types

Actions
Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Cohort Profile: The Ovarian Cancer Cohort Consortium (OC3)

Affiliations

Cohort Profile: The Ovarian Cancer Cohort Consortium (OC3)

Authors

Affiliations

Figures

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical