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Randomized Controlled Trial
. 2022 Feb;37(2):335-341.
doi: 10.1111/jgh.15705. Epub 2021 Nov 2.

Curcuma longa Linn versus omeprazole in treatment of functional dyspepsia: A randomized, double-blind, placebo-controlled trial

Kachonsak Yongwatana  1 , Kamin Harinwan  1 , Sakkarin Chirapongsathorn  1 , Krit Opuchar  1 , Theeranun Sanpajit  1 , Wanich Piyanirun  1 , Chaipichit Puttapitakpong  1
Affiliations
Randomized Controlled Trial

Curcuma longa Linn versus omeprazole in treatment of functional dyspepsia: A randomized, double-blind, placebo-controlled trial

Kachonsak Yongwatana et al. J Gastroenterol Hepatol. 2022 Feb.

Abstract

Background and aims: Functional dyspepsia (FD) is a common problem in gastroenterology practice. The study aimed to compare the efficacy of Curcuma longa Linn versus omeprazole and placebo among patients diagnosed with FD.

Methods: From November 2017 to November 2018, patients diagnosed with FD according to ROME IV criteria were enrolled. Patients were randomized into curcumin, omeprazole, or placebo groups. The Severity of Dyspepsia Assessment (SODA) was used to evaluate clinical effectiveness after 2 and 4 weeks. Health-related quality of life was assessed using the EuroQol-5 Dimension questionnaire.

Results: A total of 132 patients were randomized. Forty-five, 43, and 44 patients were in the curcumin, omeprazole, and placebo groups, respectively. At 4 weeks, the mean SODA score change of pain and non-pain symptoms decreased in the curcumin group compared with the placebo group (pain -16.98 ± 8.09 vs -10.53 ± 4.43; P < 0.001, non-pain -7.96 ± 3.41 vs -6.05 ± 3.03; P < 0.008). No significant difference was observed between curcumin and omeprazole groups (pain -16.98 ± 8.09 vs -14.69 ± 6.41; P = 0.302, non-pain -7.96 ± 3.41 vs -7.07 ± 2.27; P = 0.486). The mean change of the SODA satisfaction score at 4 weeks was higher in the curcumin group compared with the omeprazole group but without statistical significance (9.17 ± 3.88 vs 8.63 ± 3.89, P = 1). The mean change of EQ-5D index at 4 weeks was highest in the curcumin group but not statistically different from other groups (0.12 ± 0.13 vs 0.09 ± 0.10 vs 0.07 ± 0.05; P = 0.055).

Conclusion: Curcuma longa Linn can improve dyspeptic symptoms, improve quality of life, and provide satisfaction equivalent to omeprazole in treatment of FD.

Keywords: HRQOL; curcumin; functional dyspepsia; omeprazole.

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References

    1. Stanghellini V, Chan FK, Hasler WL, Malagelada JR, Suzuki H, Tack J et al. Gastroduodenal disorders. Gastroenterology 2016; 150: 1380-1392.
    1. Miwa H, Kusano M, Arisawa T, Oshima T, Kato M, Joh T et al. Evidence-based clinical practice guidelines for functional dyspepsia. J. Gastroenterol. 2015; 50: 125-139.
    1. Bytzer P, Talley NJ. Dyspepsia. Ann. Intern. Med. 2001; 134: 815-822.
    1. Sander GB, Mazzoleni LE, Francesconi CF, Balbinotto G, Mazzoleni F, Wortmann AC et al. Influence of organic and functional dyspepsia on work productivity: the HEROES-DIP study. Value Health 2011; 14: S126-S129.
    1. Yu Y, Wu S, Li J, Wang R, Xie X, Yu X et al. The effect of curcumin on the brain-gut axis in rat model of irritable bowel syndrome: involvement of 5-HT-dependent signaling. Metab. Brain Dis. 2015; 30: 47-55.

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