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Review
. 2021 Dec 1;33(6):633-638.
doi: 10.1097/MOP.0000000000001067.

Primary immunodeficiency and the microbiome

Maryam Ali Al-Nesf  1   2 , David Morgan  3 , Vidya Mohamed-Ali  4   2
Affiliations
Review

Primary immunodeficiency and the microbiome

Maryam Ali Al-Nesf et al. Curr Opin Pediatr. .

Abstract

Purpose of review: The current understanding of the relationship of the microbiota to clinical manifestation in patients with primary immunodeficiency, specifically the inflammatory processes caused by or that result in microbial dysbiosis, and their potential therapeutic options in primary immunodeficiency diseases (PID), is the basis of this review.

Recent findings: PIDs are heterogeneous diseases with variable presentations, genetic backgrounds, complications, and severity. The immune-mediators may be extrinsic, such as therapeutic regimens that patients are on, including immunoglobin, biologics, antibiotics and diet, or intrinsic, like cytokines, microRNA and microbiome. The microbiome in PID, in particular, appears to play a crucial role in helping the host's immune system maintain hemostatic control in the intestine. Many of the clinical manifestations and complications of PID may be attributed to inflammatory and immune dysregulatory processes connected to the imbalances of the diet-microbiota-host-immunity axis, as shown by data pointing to the loss of microbial diversity, dysbiosis, in PID.

Summary: The gut microbiome is a promising area of study in PID. Although the connection of the microbiome to humoral immunodeficiency is evident, the possibility of utilizing the association of humoral and cellular immunodeficiency and the microbiome for therapeutic benefit is still under investigation.

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References

    1. Bousfiha A, Jeddane L, Picard C, et al. Human inborn errors of immunity: 2019 update of the IUIS phenotypical classification. J Clin Immunol 2020; 40:66–81.
    1. Castagnoli R, Pala F, Bosticardo M, et al. Gut microbiota–host interactions in inborn errors of immunity. Int J Mol Sci 2021; 22:
    1. Fadlallah J, El Kafsi H, Sterlin D, et al. Microbial ecology perturbation in human IgA deficiency. Sci Transl Med 2018; 10:eaan1217.
    1. Berbers R, Franken I, Leavis H. Immunoglobulin A and microbiota in primary immunodeficiency diseases. Curr Opin Allergy Clin Immunol 2019; 19:563–570.
    1. Bosák J, Lexa M, Fiedorová K, et al. Patients with common variable immunodeficiency (CVID) show higher gut bacterial diversity and levels of low-abundance genes than the healthy housemates. Front Immunol 2021. 12.

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