Microarray Analysis of the Chemoprophylaxis Effect of Zinc Gluconate: Inspiring but Caution Required

Yuqing Wang¹, Wei Liu², Xinxin Xu³, Lei Yan^{4

5}

Affiliations

¹ School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
² Department of Obstetrics and Gynecology, Shanxi Bethune Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
³ Center for Reproductive Medicine, Reproductive Hospital Affiliated To Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
⁴ School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. m18660782393_1@163.com.
⁵ Center for Reproductive Medicine, Reproductive Hospital Affiliated To Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. m18660782393_1@163.com.

Comment

Yuqing Wang et al. Dig Dis Sci. 2021 Dec.

. 2021 Dec;66(12):4570-4571.

doi: 10.1007/s10620-021-07238-1. Epub 2021 Oct 15.

Yuqing Wang¹, Wei Liu², Xinxin Xu³, Lei Yan^{4

5}

¹ School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
² Department of Obstetrics and Gynecology, Shanxi Bethune Hospital, Shanxi Medical University, Taiyuan, Shanxi, China.
³ Center for Reproductive Medicine, Reproductive Hospital Affiliated To Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
⁴ School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. m18660782393_1@163.com.
⁵ Center for Reproductive Medicine, Reproductive Hospital Affiliated To Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China. m18660782393_1@163.com.

No abstract available

Comment on

Zinc Gluconate Induces Potentially Cancer Chemopreventive Activity in Barrett's Esophagus: A Phase 1 Pilot Study.
Valenzano MC, Rybakovsky E, Chen V, Leroy K, Lander J, Richardson E, Yalamanchili S, McShane S, Mathew A, Mayilvaganan B, Connor L, Urbas R, Huntington W, Corcoran A, Trembeth S, McDonnell E, Wong P, Newman G, Mercogliano G, Zitin M, Etemad B, Thornton J, Daum G, Raines J, Kossenkov A, Fong LY, Mullin JM. Valenzano MC, et al. Dig Dis Sci. 2021 Apr;66(4):1195-1211. doi: 10.1007/s10620-020-06319-x. Epub 2020 May 15. Dig Dis Sci. 2021. PMID: 32415564 Free PMC article. Clinical Trial.

1. Valenzano MC, Rybakovsky E, Chen V et al. Zinc gluconate induces potentially cancer chemopreventive activity in Barrett’s esophagus: a phase 1 pilot study. Dig Dis Sci 2021;66:1195–1211. https://doi.org/10.1007/s10620-020-06319-x . - DOI - PubMed
1. Li Q, Li N, Lao Y, Lin W, Jiang G, Wei N, Wang C, Liu K, Wu J. Variable levels of long noncoding RNA expression in DNA mismatch repair-proficient early-stage colon cancer. Dig Dis Sci 2017;62:1235–1245. https://doi.org/10.1007/s10620-017-4465-6 . - DOI - PubMed
1. Yuan B, Yang J, Gu H, Ma C. Down-regulation of LINC00460 represses metastasis of colorectal cancer via WWC2. Dig Dis Sci 2020;65:442–456. https://doi.org/10.1007/s10620-019-05801-5 . - DOI - PubMed
1. Benjamini Y, Hochberg Y. Controlling the false discovery rate—a practical and powerful approach to multiple testing. J R Stat Soc Ser B Methodol 1995;57:289–300.
1. Assefa AT, De Paepe K, Everaert C, Mestdagh P, Thas O, Vandesompele J. Differential gene expression analysis tools exhibit substandard performance for long non-coding RNA-sequencing data. Genome Biol 2018;19:96. - DOI