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. 2022 Mar;34(3):687-690.
doi: 10.1007/s40520-021-01993-x. Epub 2021 Oct 16.

Biological Frailty Index in centenarians

Beatrice Arosio  1 , Annalisa Geraci  2 , Evelyn Ferri  2 , Daniela Mari  3 , Matteo Cesari  4   5
Affiliations

Biological Frailty Index in centenarians

Beatrice Arosio et al. Aging Clin Exp Res. 2022 Mar.

Abstract

This study measured the subclinical frailty of centenarians by looking at the accumulation of their biological abnormalities. For this aim, a biological Frailty Index (FI) was computed in centenarians living in Northern Italy. The median value of the biological FI was 0.33 (interquartile range, IQR 0.28-0.41). The biological FI did not significantly differ between women (0.34, IQR 0.31-0.39) and men (0.32, IQR 0.26-0.43). The biological FI seems to have a narrower distribution compared to clinical FI we previously computed in the same cohort. In conclusion, our study suggests that centenarians benefit from exceptional biological reserves that might be underestimated by clinical appearances.

Keywords: Biological frailty index; Biological reserves; Centenarians; Longevity.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Distribution of the biological FI in centenarians
See this image and copyright information in PMC

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