doi: 10.1016/j.it.2021.09.011.
Epub 2021 Oct 13.
The meningeal lymphatics: regulators of Aβ immunotherapy?
Affiliations
- PMID: 34656427
- DOI: 10.1016/j.it.2021.09.011
Item in Clipboard
The meningeal lymphatics: regulators of Aβ immunotherapy?
Trends Immunol.
2021 Nov.
Abstract
A new study by Da Mesquita et al. reports on how meningeal lymphatic modulation may influence amyloid-beta immunotherapy and microglial function in mouse models of Alzheimer's disease (AD). This research has broad implications for unraveling the role meningeal lymphatics may play in regulating immunity in the brain during AD pathology and treatment.
Copyright © 2021 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of interests The authors declare no conflicts of interest.
Similar articles
-
Meningeal lymphatics affect microglia responses and anti-Aβ immunotherapy.Nature. 2021 May;593(7858):255-260. doi: 10.1038/s41586-021-03489-0. Epub 2021 Apr 28. Nature. 2021. PMID: 33911285 Free PMC article.
-
Connections Between Amyloid Beta and the Meningeal Lymphatics As a Possible Route for Clearance and Therapeutics.Lymphat Res Biol. 2020 Feb;18(1):2-6. doi: 10.1089/lrb.2018.0079. Epub 2019 Aug 21. Lymphat Res Biol. 2020. PMID: 31433264
-
Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease.Nature. 2018 Aug;560(7717):185-191. doi: 10.1038/s41586-018-0368-8. Epub 2018 Jul 25. Nature. 2018. PMID: 30046111 Free PMC article.
-
Borneol-driven meningeal lymphatic drainage clears amyloid-β peptide to attenuate Alzheimer-like phenotype in mice.Theranostics. 2023 Jan 1;13(1):106-124. doi: 10.7150/thno.76133. eCollection 2023. Theranostics. 2023. PMID: 36593948 Free PMC article.
-
Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework.Mol Psychiatry. 2021 Apr;26(4):1075-1097. doi: 10.1038/s41380-020-0731-7. Epub 2020 Apr 30. Mol Psychiatry. 2021. PMID: 32355332 Free PMC article. Review.
Cited by
-
Emerging Roles of Meningeal Lymphatic Vessels in Alzheimer's Disease.J Alzheimers Dis. 2023;94(s1):S355-S366. doi: 10.3233/JAD-221016. J Alzheimers Dis. 2023. PMID: 36683509 Free PMC article. Review.
-
Cranial bone maneuver ameliorates Alzheimer's disease pathology via enhancing meningeal lymphatic drainage function.Alzheimers Dement. 2025 Feb;21(2):e14518. doi: 10.1002/alz.14518. Epub 2025 Jan 30. Alzheimers Dement. 2025. PMID: 39887820 Free PMC article.
-
Drug delivery pathways to the central nervous system via the brain glymphatic system circumventing the blood-brain barrier.Exploration (Beijing). 2024 Jul 9;5(2):20240036. doi: 10.1002/EXP.20240036. eCollection 2025 Apr. Exploration (Beijing). 2024. PMID: 40395758 Free PMC article. Review.
-
Phototherapy of Alzheimer's Disease: Photostimulation of Brain Lymphatics during Sleep: A Systematic Review.Int J Mol Sci. 2023 Jun 30;24(13):10946. doi: 10.3390/ijms241310946. Int J Mol Sci. 2023. PMID: 37446135 Free PMC article.
-
Overview of the meningeal lymphatic vessels in aging and central nervous system disorders.Cell Biosci. 2022 Dec 17;12(1):202. doi: 10.1186/s13578-022-00942-z. Cell Biosci. 2022. PMID: 36528776 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical
