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. 2021 Dec;11(6):2089-2105.
doi: 10.1007/s13555-021-00613-w. Epub 2021 Oct 18.

Depression and Anxiety in Rosacea Patients: A Systematic Review and Meta-Analysis

Ru Dai  1 , BingJiang Lin  2 , Xuetong Zhang  1 , Yuchen Lou  1 , Suling Xu  3
Affiliations

Depression and Anxiety in Rosacea Patients: A Systematic Review and Meta-Analysis

Ru Dai et al. Dermatol Ther (Heidelb). 2021 Dec.

Abstract

Introduction: Depression and anxiety are common among people with rosacea. However, the exact magnitude of the prevalence rate and odds ratios (ORs) for depression and anxiety, respectively, in rosacea patients is unclear, and no systematic review or meta-analysis of published data has yet been performed. We therefore performed as systematic review and meta-analysis to determine the prevalence rates and ORs for depression and anxiety in rosacea patients.

Methods: We performed a systematic search of the PubMed, Embase and Medline databases for all observational studies published up to October 2020 that reported the prevalence rates and ORs for depression and anxiety in patients with rosacea. The primary outcome measures were prevalence rates and ORs for depression and anxiety in patients with rosacea. Heterogeneity across studies was assessed with the I2 statistic. Sources of heterogeneity were explored through subgroup and meta-regression analyses.

Results: A total of 14 studies involving 14,134,021 patients with rosacea were included in the systematic review and meta-analysis. The pooled prevalence of depression was 19.6% (95% confidence interval [CI] 15.0-24.3%) and that of anxiety was 15.6% (95% CI 11.8-19.3%). The prevalence of depression and anxiety was significantly lower in studies using clinical criteria to diagnose depression and anxiety (9.2 and 10.2%, respectively) than in those studies using screening tools (26.2% [P < 0.01] and 22.7% [P = 0.03], respectively). The methodological quality of the included studies greatly contributed to the heterogeneity. Patients with rosacea were more likely to experience depression (OR 2.21, 95% CI 1.79-2.72) and anxiety (OR 2.31, 95% CI 1.56-3.44) than healthy controls.

Conclusions: This systematic review and meta-analysis indicates that patients with rosacea are at a higher risk of experiencing depression and anxiety. More efforts are warranted to recognize and manage depression and anxiety in patients with rosacea.

Keywords: Anxiety; Depression; Prevalence; Rosacea.

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Figures

Fig. 1
Fig. 1
PRISM flow diagram of study inclusion
Fig. 2
Fig. 2
Forest plots of depression in rosacea patients. a Prevalence of depression. ES Effect size, CI confidence interval. b Association of depression in rosacea patients versus healthy controls. OR Odds ratios
Fig. 3
Fig. 3
Forest plots of anxiety in rosacea patients. a Prevalence of anxiety. b Association of anxiety in rosacea patients versus healthy controls
See this image and copyright information in PMC

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