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Review
. 2022 Jan;46(1):46-51.
doi: 10.1002/cbin.11712. Epub 2021 Oct 31.

The role of hypoxia-inducible factor 1-alpha in inflammatory bowel disease

Jiuheng Yin  1 , Yanbei Ren  1 , Kunqiu Yang  2 , Wensheng Wang  1 , Ting Wang  3 , Weidong Xiao  1 , Hua Yang  1
Affiliations
Review

The role of hypoxia-inducible factor 1-alpha in inflammatory bowel disease

Jiuheng Yin et al. Cell Biol Int. 2022 Jan.

Abstract

Inflammatory bowel disease (IBD) develops as a result of a combination of genetic predisposition, dysbiosis of the gut microbiota, and environmental influences, which is mainly represented by ulcerative colitis (UC) and Crohn's disease (CD). IBDs can result in inflammatory hypoxia by causing intestinal inflammation and vascular damage. The hypoxia-inducible factor 1-alpha (HIF-1α), as a transcription factor, can regulate the cellular adaptation to low oxygen levels and support the development and function of the gut barrier. HIF-αplays its functions through translocating into the nucleus, dimerizing with HIF-1β, and binding to hypoxia-responsive elements of HIF-1 target genes. So far, most studies have addressed the function of HIF-1α in murine models of IBD. In this review, we aim to outline the major roles of HIF-1α in the IBD.

Keywords: hypoxia-inducible factor-1 α (HIF-1α); immune cell; inflammatory bowel disease (IBD); intestinal epithelial cell (IEC).

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References

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