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. 2022 Jan;16(1):125-131.
doi: 10.1111/irv.12910. Epub 2021 Oct 17.

Estimating the burden of adult hospital admissions due to RSV and other respiratory pathogens in England

Ashley Sharp  1 , Mehdi Minaji  2 , Nikolaos Panagiotopoulos  2 , Rachel Reeves  2 , Andre Charlett  2 , Richard Pebody  2
Affiliations

Estimating the burden of adult hospital admissions due to RSV and other respiratory pathogens in England

Ashley Sharp et al. Influenza Other Respir Viruses. 2022 Jan.

Abstract

Respiratory syncytial virus (RSV) is a common seasonal respiratory virus and an important cause of illness among infants, but the burden of RSV disease is not well described among the older population. The objective of this study was to estimate the age-specific incidence of hospital admission among over 65 s due to respiratory illnesses attributable to RSV in England to inform optimal vaccine and therapeutic interventions. We used linear multiple regression to examine the effect of changes in weekly counts of respiratory pathogens on the weekly counts of respiratory hospital admissions. The study population was all patients aged 65 years or over admitted to English hospitals between 2nd August 2010 and 30th July 2017. RSV was estimated to account for a seasonal annual average of 71 (95% CI 52-90) respiratory admissions per 100 000 in adults age 65-74 and 251 (95% CI 186-316) admissions per 100,000 adults age 75+. Pneumococcus was the pathogen responsible for highest annual average respiratory admission with 448 (95% CI 310-587) admissions per 100,000 adults age 65-74 and 1010 (95% CI 527-1493) admissions per 100,000 adults aged 75+. This study shows that RSV continues to exert a significant burden of disease among older adults in England. These findings will support development of policy for the use of RSV therapeutics and vaccines in this age group.

Keywords: burden of disease; hospital admission; respiratory; respiratory syncytial virus; time series analysis.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

FIGURE 1
FIGURE 1
Weekly observed and predicted respiratory (J00–J99) admissions attributable to each pathogen, age 65–74
FIGURE 2
FIGURE 2
Weekly observed and predicted respiratory (J00–J99) admissions attributable to each pathogen, age 75+
FIGURE 3
FIGURE 3
RSV attributable respiratory (J00–J99) admission rate by season and age group, 95% CI
See this image and copyright information in PMC

References

    1. Bosco E, Van Aalst R, McConeghy KW, et al. Estimated cardiorespiratory hospitalizations attributable to influenza and respiratory syncytial virus among long‐term care facility residents. JAMA Netw Open. 2021;4(6):e2111806. - PMC - PubMed
    1. Branche AR, Saiman L, Walsh EE, et al. Incidence of respiratory syncytial virus infection among hospitalized adults, 2017‐2020. Clin Infect Dis. 2021. - PubMed
    1. Jackson ML, Scott E, Kuypers J, Nalla AK, Roychoudury P, Chu HY. Epidemiology of respiratory syncytial virus across five influenza seasons among adults and children one year of age and older‐Washington State, 2011/2012‐2015/2016. J Infect Dis. 2021;223(1):147‐156. - PubMed
    1. Lee N, Smith S, Zelyas N, et al. Burden of noninfluenza respiratory viral infections in adults admitted to hospital: analysis of a multiyear Canadian surveillance cohort from 2 centres. Cmaj. 2021;193(13):E439‐e446. - PMC - PubMed
    1. Prasad N, Newbern EC, Trenholme AA, et al. The health and economic burden of respiratory syncytial virus associated hospitalizations in adults. PLoS One. 2020;15(6):e0234235. - PMC - PubMed