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Comment
. 2021 Oct 18:10:e73739.
doi: 10.7554/eLife.73739.

Preparing for implantation

J Julie Kim  1
Affiliations
Comment

Preparing for implantation

J Julie Kim. Elife. .

Abstract

A new laboratory model helps to understand the role of senescent cells in fostering a uterine environment that can support an embryo.

Keywords: assembloid; cell biology; decidualisation; embryo implantation; endometrium; human; organoid; senescence.

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Conflict of interest statement

JK No competing interests declared

Figures

Figure 1.
Figure 1.. Senescent decidual cells promote embryo expansion and movement.
Rawlings et al. developed endometrial assembloids and exposed them to hormones to help their differentiation process. These models contain both stromal (round) and epithelial (trapezoid) cells. The three subpopulations of stromal cells are shown (predecidual in blue; decidual in orange; and senescent decidual in red). Assembloids not treated with the tyrosine kinase inhibitor dasatinib (left) promote the expansion and movement of an embryo (oval-shaped structure). Treatment with the drug (right) causes senescent decidual cells to be eliminated from the assembloid, which prevents the expansion of the embryo and restricts its movement.
See this image and copyright information in PMC

Comment on

References

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