Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Dec:134:108995.
doi: 10.1016/j.inoche.2021.108995. Epub 2021 Oct 8.

Recent development for biomedical applications of magnetic nanoparticles

Atta Ullah Khan  1 , Lan Chen  1 , Guanglu Ge  1
Affiliations
Review

Recent development for biomedical applications of magnetic nanoparticles

Atta Ullah Khan et al. Inorg Chem Commun. 2021 Dec.

Abstract

In recent decades, the use of engineered nanoparticles has been increasing in various sectors, including biomedicine, diagnosis, water treatment, and environmental remediation leading to significant public concerns. Among these nanoparticles, magnetic nanoparticles (MNPs) have gained many attentions in medicine, pharmacology, drug delivery system, molecular imaging, and bio-sensing due to their various properties. In addition, various studies have reviewed MNPs main applications in the biomedical engineering area with intense progress and recent achievements. Nanoparticles, especially the magnetic nanoparticles, have recently been confirmed with excellent antiviral activity against different viruses, including SARS-CoV-2(Covid-19) and their recent development against Covid-19 also has also been discussed. This review aims to highlight the recent development of the magnetic nanoparticles and their biomedical applications such as diagnosis of diseases, molecular imaging, hyperthermia, bio-sensing, gene therapy, drug delivery and the diagnosis of Covid-19.

Keywords: Bio-sensing; Biomedical applications; Covid-19; Magnetic nanoparticles; Molecular imaging.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

None
Graphical abstract
Fig. 1
Fig. 1
Various Biomedical uses of MNPs for diagnosis and therapy.
Fig. 2
Fig. 2
a) polymeric gene delivery system and b) process of Magnetofection.
Fig. 3
Fig. 3
Drug targeted delivery with MNPs mechanism with external magnetic field for cancer treatment.
Fig. 4
Fig. 4
Hyperthermia therapy mechanisms with external magnetic field for cancer treatment.
Fig. 5
Fig. 5
Schematic illustration of MNPs based detection method for capturing and concentrating target cells of E.coli.
Fig. 6
Fig. 6
Schematic illustration of IONPs contrast agent for the diagnosis of cancer with MRI.
Fig. 7
Fig. 7
Schematic illustration of erythrocyte membrane cloaked MNPs. Copyright 2017, American Chemical Society.
Fig. 8
Fig. 8
Schematic procedure for surface functionalized MNP’s assisted RNA-extraction. Copyright 2020 Taylor & Francis.
See this image and copyright information in PMC

References

    1. Hussain I., Singh N.B., Singh A., Singh H., Singh S.C. Green synthesis of nanoparticles and its potential application. Biotechnol. Lett. 2016;38(4):545–560. - PubMed
    1. Saxena A., Tripathi R.M., Zafar F., Singh P. Green synthesis of silver nanoparticles using aqueous solution of Ficus benghalensis leaf extract and characterization of their antibacterial activity. Mater. Lett. 2012;67(1):91–94.
    1. Fakhari S., Jamzad M., Kabiri Fard H. Green synthesis of zinc oxide nanoparticles: a comparison. Green Chem. Lett. Rev. 2019;12(1):19–24.
    1. Hemalatha K., Madhumitha G., Kajbafvala A., Anupama N., Sompalle R., Mohana Roopan S. Function of nanocatalyst in chemistry of organic compounds revolution: an overview. J. Nanomater. 2013;2013:1–23.
    1. Hebbalalu D., Lalley J., Nadagouda M.N., Varma R.S. Greener techniques for the synthesis of silver nanoparticles using plant extracts, enzymes, bacteria, biodegradable polymers, and microwaves. ACS Sustainable Chem. Eng. 2013;1(7):703–712.

LinkOut - more resources