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. 2021 Oct 1:15:755056.
doi: 10.3389/fnins.2021.755056. eCollection 2021.

Association of Serum Uric Acid Levels in Meige's Syndrome

Haochen Guan  1 , Zhi Geng  2 , Weijie Yuan  1 , Bowen Chang  3
Affiliations

Association of Serum Uric Acid Levels in Meige's Syndrome

Haochen Guan et al. Front Neurosci. .

Abstract

Uric acid (URIC) is a natural antioxidant, and it has been shown that low levels of URIC could be a risk factor for the development of Parkinson's disease. Our aim was to investigate whether URIC also plays a role in Meige's syndrome (MS). We conducted a cohort study to compare serum URIC levels between patients with MS and healthy controls. In addition, we analyzed the impact of URIC on the risk of MS and symptom severity. Compared with normal subjects, URIC content was remarkably decreased in MS patients. In addition, URIC was regarded as a protective factor for MS, as verified by multivariate logistic regression models. We also found non-linear relationships between the levels of serum URIC and the incidence rate of MS and the Burke-Fahn-Marsden dystonia rating scale score. Our study is the first to show a connection between serum URIC levels and MS. Low serum URIC levels indicate an increased risk of MS incidence and more severe clinical symptoms. Our findings provide new insights into the prevention and treatment of MS.

Keywords: Burke-Fahn-Marsden dystonia rating scale score; Meige’s syndrome; antioxidants; movement disorders; uric acid.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The diagnostic value of serum uric acid levels was evaluated using receiver operating characteristic analysis testing patients with Meige’s syndrome against healthy controls.
FIGURE 2
FIGURE 2
The association of serum uric acid levels between the incidence rate of Meige’s syndrome. The adjusted data for the incidence rate of Meige’s syndrome is plotted against serum uric acid levels with a curve indicating the shaped relationship between the two. A threshold serum uric acid level of 337 μmol/L existed for the regulation of uric acid.
FIGURE 3
FIGURE 3
The association between serum uric acid levels and Burke-Fahn-Marsden dystonia rating scale scores. A non-linear relationship was observed, and a threshold serum uric acid of 330 μmol/L existed for the regulation of uric acid.
See this image and copyright information in PMC

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