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. 2021 Sep 30:12:742937.
doi: 10.3389/fpsyt.2021.742937. eCollection 2021.

Association Between Peripheral Blood Levels of Vitamin A and Autism Spectrum Disorder in Children: A Meta-Analysis

Ni Wang  1 , Yuqian Zhao  2 , Junwei Gao  3
Affiliations

Association Between Peripheral Blood Levels of Vitamin A and Autism Spectrum Disorder in Children: A Meta-Analysis

Ni Wang et al. Front Psychiatry. .

Abstract

Vitamin A is an essential fat-soluble micronutrient that plays important roles in a surprisingly wide variety of biological processes from early growth and development to brain maintenance. Numerous clinical studies have been conducted to explore the relationship between peripheral vitamin A levels and autism spectrum disorder (ASD), but the results of these studies are controversial. Therefore, we assessed the association between peripheral vitamin A levels and ASD in the present meta-analysis. Relevant records were retrieved through the Embase, Web of Knowledge and PubMed databases up to 13 November 2020. Reference lists were also searched and analyzed. Hedges' g with its corresponding 95% confidence interval (CI) was used to assess the association between peripheral vitamin A levels and ASD. A fixed or random effects model was selected according to a heterogeneity test in overall and subgroup analyses. Five records (six studies) with 935 ASD children and 516 healthy children were included in the present study. Significantly decreased peripheral vitamin A concentrations were observed in ASD children compared with healthy children (Hedges' g = -0.600, 95% CI -1.153 to -0.048, P = 0.033). A similar result was also obtained after removing the studies identified by Galbraith plots. In addition, no obvious publication bias was found in the meta-analysis. The findings of our meta-analysis suggested decreased peripheral vitamin A levels in ASD children compared with healthy children. Further investigations into the effects of vitamin A on the development of ASD are warranted.

Keywords: association; autism spectrum disorder; peripheral blood; serum; vitamin A.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of study identification.
Figure 2
Figure 2
Forest plot for the random-effects meta-analysis.
Figure 3
Figure 3
Forest plot for the random-effects meta-analysis of the serum subgroup.
Figure 4
Figure 4
Forest plot for the random-effects meta-analysis of the Chinese subgroup.
See this image and copyright information in PMC

References

    1. Xu G, Strathearn L, Liu B, Bao W. Prevalence of autism spectrum disorder among US children and adolescents, 2014-2016. JAMA. (2018) 319:81–2. 10.1001/jama.2017.17812 - DOI - PMC - PubMed
    1. Simonoff E, Pickles A, Charman T, Chandler S, Loucas T, Baird G. Psychiatric disorders in children with autism spectrum disorders: prevalence, comorbidity, and associated factors in a population-derived sample. J Am Acad Child Adolesc Psychiatry. (2008) 47:921–9. 10.1097/CHI.0b013e318179964f - DOI - PubMed
    1. Hudepohl MB, Robins DL, King TZ, Henrich CC. The role of emotion perception in adaptive functioning of people with autism spectrum disorders. Autism. (2015) 19:107–12. 10.1177/1362361313512725 - DOI - PubMed
    1. Bai D, Yip BHK, Windham GC, Sourander A, Francis R, Yoffe R, et al. Association of genetic and environmental factors with autism in a 5-country cohort. JAMA Psychiatry. (2019) 76:1035–43. 10.1001/jamapsychiatry.2019.1411 - DOI - PMC - PubMed
    1. Masini E, Loi E, Vega-Benedetti AF. An overview of the main genetic, epigenetic and environmental factors involved in autism spectrum disorder focusing on synaptic activity. Int J Mol Sci. (2020) 21:8290. 10.3390/ijms21218290 - DOI - PMC - PubMed

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