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. 2021 Oct 10:14:17562864211050028.
doi: 10.1177/17562864211050028. eCollection 2021.

Cyclophosphamide in highly aggressive Marburg-like multiple sclerosis

Tommaso Nicoletti  1 , Assunta Bianco  1 , Matteo Lucchini  2 , Simona Gaudino  3 , Giovanni Frisullo  1 , Massimiliano Mirabella  2
Affiliations

Cyclophosphamide in highly aggressive Marburg-like multiple sclerosis

Tommaso Nicoletti et al. Ther Adv Neurol Disord. .
No abstract available

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Conflict of interest statement

Conflict of interest statement: The authors declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article.

Figures

Figure 1.
Figure 1.
Brain magnetic resonance imaging (MRI). (a–e) MRI at symptom onset: (a) axial T1-weighted image showing an area of mild myelin rarefaction (hypointense signal) in the left corona radiata (orange arrowhead), (b) T1-weighted image after administration of gadolinium depicting a nodular contrast enhancement pattern, (c) axial fluid-attenuated inversion recovery (FLAIR) image illustrating the left tumefactive demyelinating lesion (TDL) and a small hyperintense area of the contralateral white matter, (d) TDL exhibiting restricted diffusion at diffusion-weighted imaging (DWI) and (e) TDL was markedly hypointense on apparent diffusion coefficient map. (f–i) Follow-up MRI (1 week after symptoms onset): (f) axial FLAIR image showing extension of TDL with areas of demyelination also involving the right hemisphere, (g) axial DWI image, (h) sagittal T2-weighted image and (i) axial T1-weighted image showing a linear-marginal contrast enhancement pattern. (j) Follow-up MRI (4 weeks after symptom onset): coronal FLAIR image depicting massive bilateral involvement of subcortical structures. (k) Summary of disease course.
See this image and copyright information in PMC

References

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