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. 2021 Sep 21;12(22):6695-6705.
doi: 10.7150/jca.62734. eCollection 2021.

Global changing trends in incidence and mortality of gastric cancer by age and sex, 1990-2019: Findings from Global Burden of Disease Study

Tongchao Zhang  1   2 , Hui Chen  1   2 , Yuan Zhang  1   2 , Xiaolin Yin  1   2   3 , Jinyu Man  1   2   3 , Xiaorong Yang  1   2   4 , Ming Lu  1   2   3
Affiliations

Global changing trends in incidence and mortality of gastric cancer by age and sex, 1990-2019: Findings from Global Burden of Disease Study

Tongchao Zhang et al. J Cancer. .

Abstract

Background: The global disease burden of gastric cancer (GC) is still heavy. Understanding the patterns and trends of the global GC burden is important for developing precise prevention strategies. Materials and Methods: The data of GC burden were retrieved from the Global Burden of Disease Study (2019). The estimated annual percentage change (EAPC) was calculated to estimate the temporal trends of the age-standardized incidence and mortality rates (ASIR and ASMR) of global GC by age-specific groups (15-49, 50-69, and ≥70 years), sexes, socio-demographic indexes (SDIs), regions, and countries. Results: In 2019, the ASIR and ASMR of global GC increased with age in both sexes, and reached a peak in the older 70 age group. The ASIR and ASMR in males were higher than those in females. From 1990 to 2019, the global number of GC incident cases increased in both sexes in all age-specific groups; while the ASIR of GC decreased, and the most significant decrease was observed in the 50-69 age group [males: EAPC=-1.34, 95% CI: (-1.49, -1.18); females: EAPC= -2.09, 95% CI: (-2.22, -1.96)]. During the study period, downward trends in ASIR of GC were observed in both sexes in most SDI regions, GBD regions, and countries. Similar trends in ASMR of GC were also observed. Conclusion: The global GC incidence and mortality rates decreased from 1990 to 2019 in both sexes, most GBD regions, and most countries. However, the GC burden was still heavy in some GBD regions and countries in special age-specific groups. It is important to formulate and implement tertiary prevention strategies based on the GC burden of age-specific groups in different regions and countries.

Keywords: Epidemiology; Gastric cancer; Global; Incidence; Mortality; Temporal trend.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interest exists.

Figures

Figure 1
Figure 1
Temporal trends in the age-standardized incidence and mortality rates of gastric cancer in age-specific groups by sex and sociodemographic index (SDI) region from 1990 to 2019.
Figure 2
Figure 2
The world map of estimated average percentage change (EAPC) in the age-standardized incidence rates of gastric cancer by sex and age-specific groups from 1990 to 2019.
Figure 3
Figure 3
The world map of estimated average percentage change (EAPC) in the age-standardized mortality rates of gastric cancer by sex and age-specific groups from 1990 to 2019.
See this image and copyright information in PMC

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