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Review
. 2021 Nov:71:102898.
doi: 10.1016/j.amsu.2021.102898. Epub 2021 Oct 8.

Central Retinal Vein Occlusion in patients with COVID-19 infection: A systematic review

Irfan Ullah  1 , Aruba Sohail  2 , Mir Umer Farooq Alam Shah  2 , Maman Khurshid  2 , Mufaddal Najmuddin Diwan  2 , Abdul Qadir  3 , Muhammad Irfan  4
Affiliations
Review

Central Retinal Vein Occlusion in patients with COVID-19 infection: A systematic review

Irfan Ullah et al. Ann Med Surg (Lond). 2021 Nov.

Abstract

This systematic review summarizes the evidence on patients diagnosed with central retinal vein occlusion (CRVO) secondary to COVID-19. We searched PubMed and Google Scholar from its inception till June 2021. From an initial 55 publications, 10 studies provided specific information on COVID-19 patients with CRVO. Studies described 10 patients, 60% were male and the mean age was 39.3 ± 11.6 years. Blurred vision (40%) and decreased vision (50%) were the most common presenting complain. Symptom onset ranged from 5 days to 6 weeks after initial complaint of fever. Laboratory results showed elevated inflammatory markers and D-dimers in 60% of patients included in our review. Common treatment options were intravitreal anti-VEGF injections, steroids, and anticoagulants. Traditional co-morbidities like diabetes mellites, hypertension, and morbid obesity (hyperlipidemia) were observed in only 3/10 patients. The prognosis was excellent as all patients saw improvement in their condition. Our findings highlight the importance of identifying CRVO as an important complication of COVID-19 infection. Thus, physicians should not overlook the likelihood of CRVO in patients with COVID-19 infection and offer prompt treatment.

Keywords: COVID-19; CRVO; Central retinal vein occlusion; Pandemic.

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Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
The flow chart of selected studies.
See this image and copyright information in PMC

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