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. 1986 Jul;6(7):2571-5.
doi: 10.1128/mcb.6.7.2571-2575.1986.

Expression of the erythropoietin gene

N Beru, J McDonald, C Lacombe, E Goldwasser

Expression of the erythropoietin gene

N Beru et al. Mol Cell Biol. 1986 Jul.

Abstract

Injection of cobalt into rats resulted in erythropoietin (EPO) mRNA accumulation in the kidney. The same response was obtained upon bleeding. No EPO mRNA was detected in the spleen, salivary gland, or thymus following cobalt injection or bleeding. In some animals, but not in others, EPO mRNA was also expressed in the liver in response to cobalt injection. Time course studies showed that message appearance begins sometime between 3 and 6 h after cobalt injection. This correlated very well with the EPO concentration in the circulation; EPO levels in the circulation were the same as those of controls at 3 h but increased to six- to sevenfold that of controls by 6 h after cobalt injection. The mature EPO mRNA in the rat and mouse comigrated with the 18S rRNA, indicating that it is about 1,850 nucleotides in length.

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