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Review
. 2021 Oct 7:2021:3331865.
doi: 10.1155/2021/3331865. eCollection 2021.

Impact of Incretin-Based Therapies on Adipokines and Adiponectin

Habib Yaribeygi  1 , Mina Maleki  2 , Stephen L Atkin  3 , Tannaz Jamialahmadi  4   5 , Amirhossein Sahebkar  6   7   8
Affiliations
Review

Impact of Incretin-Based Therapies on Adipokines and Adiponectin

Habib Yaribeygi et al. J Diabetes Res. .

Abstract

Adipokines are a family of hormones and cytokines with both pro- and anti-inflammatory effects released into the circulation to exert their hormonal effects. Adipokines are closely involved in most metabolic pathways and play an important modulatory role in lipid and carbohydrate homeostasis as they are involved in the pathophysiology of most metabolic disorders. Incretin-based therapy is a newly introduced class of antidiabetic drugs that restores euglycemia through several cellular processes; however, its effect on adipokines expression/secretion is not fully understood. In this review, we propose that incretin-based therapy may function through adipokine modulation that may result in pharmacologic properties beyond their direct antidiabetic effects, resulting in better management of diabetes and diabetes-related complications.

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Conflict of interest statement

The authors declare that they have no conflict of interest in this study.

Figures

Figure 1
Figure 1
Schematic mechanism of action of incretin-based medications.
See this image and copyright information in PMC

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