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Comment
. 2021 Nov 1;220(11):e202109019.
doi: 10.1083/jcb.202109019. Epub 2021 Oct 18.

The staying power of hematopoietic stem cells

Michael L Dustin  1
Affiliations
Comment

The staying power of hematopoietic stem cells

Michael L Dustin. J Cell Biol. .

Abstract

Hematopoietic stem and progenitor cells (HSPCs) use specialized adhesive structures referred to as magnupodium to stay in hematopoietic niches. Bessey et al. (2021. J. Cell Biol.https://doi.org/10.1083/jcb.202005085) define new characteristics of the magnupodium, including centriole polarization and the necessary and sufficient role of CXCR4 signaling.

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Figures

Figure 1.
Figure 1.
Magnupodium formation between HSPCs and osteoblasts and reductionist models. (A) Schematic of HSPC formation of a magnupodium with an osteoblast and potential receptor ligand interactions and cytoskeletal machinery. (B) Magnupodium-like structure formed by EBV transformed B cell on purified LFA-1. LMP, latent membrane protein (7). (C) Magnupodium formation in response to laterally mobile VCAM and mSCF (10).
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References

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