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. 2022 Feb;40(2):145-148.
doi: 10.1016/j.tibtech.2021.09.008. Epub 2021 Oct 16.

Proximity labeling: an enzymatic tool for spatial biology

Chang-Ryul Choi  1 , Hyun-Woo Rhee  2
Affiliations

Proximity labeling: an enzymatic tool for spatial biology

Chang-Ryul Choi et al. Trends Biotechnol. 2022 Feb.

Abstract

In this Forum, we highlight how cutting-edge, proximity-dependent, enzymatic labeling tools, aided by sequencing technology developments, have enabled the extraction of spatial information of proteomes, transcriptomes, genome organization, and cellular networks. We also discuss the potential applications of proximity labeling in the unexplored field of spatial biology in live systems.

Keywords: APEX; TurboID; cell–cell interaction network; proximity labeling; spatial biology.

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Conflict of interest statement

Declaration of interests No conflicts of interest are declared.

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