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Comment
. 2021 Oct;129(10):104003.
doi: 10.1289/EHP10301. Epub 2021 Oct 19.

Autism in Three Dimensions: Using Brain Organoids to Study Potential Gene-Environment Interactions

Silke Schmidt
Comment

Autism in Three Dimensions: Using Brain Organoids to Study Potential Gene-Environment Interactions

Silke Schmidt. Environ Health Perspect. 2021 Oct.
No abstract available

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Figures

Micrographs showing neurites emerging from exposed and control brain organoids
Graphical abstract
Micrographs showing neurites emerging from exposed and control brain organoids
These micrographs show 4-week brain organoids that carry the CHD8 mutation. Organoids exposed to chlorpyrifos (left) exhibited impaired length and density of neurites, shown in green, compared with untreated controls (right). Neurite outgrowth is a sensitive functional end point for demonstrating how genetics, environment, or both can impair neurodevelopment. Images: Courtesy Xiali Zhong/The Johns Hopkins University.
See this image and copyright information in PMC

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