An MRI-based radiomics-clinical nomogram for the overall survival prediction in patients with hypopharyngeal squamous cell carcinoma: a multi-cohort study

Juan Chen^#^{1

2

3}, Shanhong Lu^#^{1

2

3}, Yitao Mao⁴, Lei Tan⁵, Guo Li^{1

2

3}, Yan Gao^{1

2

3}, Pingqing Tan⁶, Donghai Huang^{1

2

3

7}, Xin Zhang^{1

2

3

7}, Yuanzheng Qiu^{8

9

10

11}, Yong Liu^{12

13

14

15}

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.
² Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, 410008, Hunan, China.
³ Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province, Changsha, 410008, Hunan, China.
⁴ Department of Radiology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
⁵ College of Computer and Information Engineering, Hunan University of Technology and Business, Changsha, 410205, Hunan, China.
⁶ Department of Head and Neck Surgery, The Affiliated Tumor Hospital of Xiangya Medical School, Hunan Cancer Hospital, Central South University, Changsha, 410013, Hunan, China.
⁷ National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Xiangya Road, Changsha, 410008, Hunan, China.
⁸ Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. xyqyz@csu.edu.cn.
⁹ Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, 410008, Hunan, China. xyqyz@csu.edu.cn.
¹⁰ Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province, Changsha, 410008, Hunan, China. xyqyz@csu.edu.cn.
¹¹ National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Xiangya Road, Changsha, 410008, Hunan, China. xyqyz@csu.edu.cn.
¹² Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. liuyongent@csu.edu.cn.
¹³ Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, 410008, Hunan, China. liuyongent@csu.edu.cn.
¹⁴ Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province, Changsha, 410008, Hunan, China. liuyongent@csu.edu.cn.
¹⁵ National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Xiangya Road, Changsha, 410008, Hunan, China. liuyongent@csu.edu.cn.

^# Contributed equally.

PMID: 34665315
DOI: 10.1007/s00330-021-08292-z

An MRI-based radiomics-clinical nomogram for the overall survival prediction in patients with hypopharyngeal squamous cell carcinoma: a multi-cohort study

Juan Chen et al. Eur Radiol. 2022 Mar.

. 2022 Mar;32(3):1548-1557.

doi: 10.1007/s00330-021-08292-z. Epub 2021 Oct 19.

Authors

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China.
² Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, 410008, Hunan, China.
³ Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province, Changsha, 410008, Hunan, China.
⁴ Department of Radiology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
⁵ College of Computer and Information Engineering, Hunan University of Technology and Business, Changsha, 410205, Hunan, China.
⁶ Department of Head and Neck Surgery, The Affiliated Tumor Hospital of Xiangya Medical School, Hunan Cancer Hospital, Central South University, Changsha, 410013, Hunan, China.
⁷ National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Xiangya Road, Changsha, 410008, Hunan, China.
⁸ Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. xyqyz@csu.edu.cn.
⁹ Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, 410008, Hunan, China. xyqyz@csu.edu.cn.
¹⁰ Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province, Changsha, 410008, Hunan, China. xyqyz@csu.edu.cn.
¹¹ National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Xiangya Road, Changsha, 410008, Hunan, China. xyqyz@csu.edu.cn.
¹² Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, 410008, Hunan, China. liuyongent@csu.edu.cn.
¹³ Otolaryngology Major Disease Research Key Laboratory of Hunan Province, Changsha, 410008, Hunan, China. liuyongent@csu.edu.cn.
¹⁴ Clinical Research Center for Pharyngolaryngeal Diseases and Voice Disorders in Hunan Province, Changsha, 410008, Hunan, China. liuyongent@csu.edu.cn.
¹⁵ National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Xiangya Road, Changsha, 410008, Hunan, China. liuyongent@csu.edu.cn.

^# Contributed equally.

PMID: 34665315
DOI: 10.1007/s00330-021-08292-z

Abstract

Objective: To explore whether radiomics features extracted from pre-treatment magnetic resonance imaging (MRI) can predict the overall survival (OS) in patients with hypopharyngeal squamous cell carcinoma.

Methods: A total of 190 patients with hypopharyngeal squamous cell carcinoma were eligibly enrolled from two institutions. Radiomics features were extracted from contrast-enhanced axial T1-weighted (CE-T1WI) sequence. The least absolute shrinkage selection operator (LASSO) algorithm was applied to establish a radiomics score correlated with OS. Multivariate logistic regression analysis was applied to determine the independent risk factors, which was combined with radiomics score to build the final radiomics nomogram.

Results: A radiomics score with 6 CE-T1WI features for OS prediction was constructed and validated; its integration with specific clinicopathologic factors (N stage) showed a better prediction performance in the training, internal validation, and external validation cohorts (C-index 0.78, 0.75, and 0.75). Calibration curves determined a good agreement between the predicted and actual overall survival.

Conclusions: The radiomics-clinical nomogram and radiomics score might be non-invasive and reliable methods for the risk stratification in patients with hypopharyngeal squamous cell carcinoma.

Key points: • An MRI-based radiomics model was constructed to evaluate of OS in patients with hypopharyngeal squamous cell carcinoma. • A radiomics-clinical nomogram that combined radiomics features and clinical characteristics was established. • Multi-cohort study validated the predictive performance of the radiomics-clinical nomogram to stratify patients with high risk in clinical practice.

Keywords: Hypopharyngeal squamous cell carcinoma; Magnetic resonance imaging; Nomogram; Prognosis; Radiomics.

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References

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An MRI-based radiomics-clinical nomogram for the overall survival prediction in patients with hypopharyngeal squamous cell carcinoma: a multi-cohort study

Affiliations

An MRI-based radiomics-clinical nomogram for the overall survival prediction in patients with hypopharyngeal squamous cell carcinoma: a multi-cohort study

Authors

Affiliations

Abstract

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Medical